Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease
Long non-coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney in...
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KeAi Communications Co., Ltd.
2019
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oai:doaj.org-article:24cb48f45de84565b937e714e3c0f47b2021-12-02T14:20:49ZLong non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease2095-882X10.1016/j.cdtm.2019.12.004https://doaj.org/article/24cb48f45de84565b937e714e3c0f47b2019-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X19300908https://doaj.org/toc/2095-882XLong non-coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma (RCC). Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment. Keywords: Long non-coding RNAs, Kidney disease, Renal inflammation, Renal fibrosis, Diabetic nephritis, Renal cell carcinomaQin ZhouWei ChenXue-Qing YuKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 5, Iss 4, Pp 252-257 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
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Medicine (General) R5-920 Qin Zhou Wei Chen Xue-Qing Yu Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease |
| description |
Long non-coding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury (AKI), chronic kidney disease (CKD), and renal cell carcinoma (RCC). Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment. Keywords: Long non-coding RNAs, Kidney disease, Renal inflammation, Renal fibrosis, Diabetic nephritis, Renal cell carcinoma |
| format |
article |
| author |
Qin Zhou Wei Chen Xue-Qing Yu |
| author_facet |
Qin Zhou Wei Chen Xue-Qing Yu |
| author_sort |
Qin Zhou |
| title |
Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease |
| title_short |
Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease |
| title_full |
Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease |
| title_fullStr |
Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease |
| title_full_unstemmed |
Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease |
| title_sort |
long non-coding rnas as novel diagnostic and therapeutic targets in kidney disease |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2019 |
| url |
https://doaj.org/article/24cb48f45de84565b937e714e3c0f47b |
| work_keys_str_mv |
AT qinzhou longnoncodingrnasasnoveldiagnosticandtherapeutictargetsinkidneydisease AT weichen longnoncodingrnasasnoveldiagnosticandtherapeutictargetsinkidneydisease AT xueqingyu longnoncodingrnasasnoveldiagnosticandtherapeutictargetsinkidneydisease |
| _version_ |
1718391536779001856 |