Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies

Steven J Greco1, Pranela Rameshwar21Graduate School of Biomedical Sciences; 2Department of Medicine, Division of Hematology/Oncology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USAAbstract: The therapeutic utilization of stem cells has been ongoing for...

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Autores principales:	Steven J Greco, Pranela Rameshwar
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/24cc511dba764a3591eedd9828259efa
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spelling	oai:doaj.org-article:24cc511dba764a3591eedd9828259efa2021-12-02T00:29:21ZMicroenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies1177-54751177-5491https://doaj.org/article/24cc511dba764a3591eedd9828259efa2008-10-01T00:00:00Zhttp://www.dovepress.com/microenvironmental-considerations-in-the-application-of-human-mesenchy-a2387https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Steven J Greco1, Pranela Rameshwar21Graduate School of Biomedical Sciences; 2Department of Medicine, Division of Hematology/Oncology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USAAbstract: The therapeutic utilization of stem cells has been ongoing for several decades, principally in the form of bone marrow (BM) transplants to treat various hematological disorders and other immune-related diseases. More recently, stem cells have been examined as a potential therapy for a multitude of other diseases and disorders, many of which are currently untreatable. One consideration that poses a formidable task for the successful clinical application of stem cells in new disease models is the impact of the host tissue microenvironment on the desired therapeutic outcome. In vitro, stem cells exist in surroundings directly controllable by the researcher to produce the desired cellular behavior. In vivo, the transplanted cells are exposed to a dynamic host microenvironment laden with soluble mediators and immunoreactive cells. In this review, we focus on the possible contribution by microenvironmental factors, and how these influences can be overcome in therapies utilizing mesenchymal stem cells (MSCs), such as for graft versus host disease, multiple sclerosis and ischemia among others. Specifically, we examine three ubiquitous microenvironmental factors, IL-1&alpha;/&beta;, TNF&alpha;, and SDF-1&alpha;, and consider how inhibitors and receptor antagonists to these molecules could be applied to increase the efficacy of MSC therapies while minimizing unforeseen harm to the patient.Keywords: cytokine, microenvironment, mesenchymal stem cells, bone marrow Steven J GrecoPranela RameshwarDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 699-705 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Steven J Greco Pranela Rameshwar Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
description	Steven J Greco1, Pranela Rameshwar21Graduate School of Biomedical Sciences; 2Department of Medicine, Division of Hematology/Oncology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USAAbstract: The therapeutic utilization of stem cells has been ongoing for several decades, principally in the form of bone marrow (BM) transplants to treat various hematological disorders and other immune-related diseases. More recently, stem cells have been examined as a potential therapy for a multitude of other diseases and disorders, many of which are currently untreatable. One consideration that poses a formidable task for the successful clinical application of stem cells in new disease models is the impact of the host tissue microenvironment on the desired therapeutic outcome. In vitro, stem cells exist in surroundings directly controllable by the researcher to produce the desired cellular behavior. In vivo, the transplanted cells are exposed to a dynamic host microenvironment laden with soluble mediators and immunoreactive cells. In this review, we focus on the possible contribution by microenvironmental factors, and how these influences can be overcome in therapies utilizing mesenchymal stem cells (MSCs), such as for graft versus host disease, multiple sclerosis and ischemia among others. Specifically, we examine three ubiquitous microenvironmental factors, IL-1&alpha;/&beta;, TNF&alpha;, and SDF-1&alpha;, and consider how inhibitors and receptor antagonists to these molecules could be applied to increase the efficacy of MSC therapies while minimizing unforeseen harm to the patient.Keywords: cytokine, microenvironment, mesenchymal stem cells, bone marrow
format	article
author	Steven J Greco Pranela Rameshwar
author_facet	Steven J Greco Pranela Rameshwar
author_sort	Steven J Greco
title	Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
title_short	Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
title_full	Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
title_fullStr	Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
title_full_unstemmed	Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
title_sort	microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/24cc511dba764a3591eedd9828259efa
work_keys_str_mv	AT stevenjgreco microenvironmentalconsiderationsintheapplicationofhumanmesenchymalstemcellsinregenerativetherapies AT pranelarameshwar microenvironmentalconsiderationsintheapplicationofhumanmesenchymalstemcellsinregenerativetherapies
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Microenvironmental considerations in the application of human mesenchymal stem cells in regenerative therapies

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