Multiscale criticality measures as general-purpose gauges of proper brain function

Abstract The brain is universally regarded as a system for processing information. If so, any behavioral or cognitive dysfunction should lend itself to depiction in terms of information processing deficiencies. Information is characterized by recursive, hierarchical complexity. The brain accommodate...

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Autores principales:	Tomer Fekete, Hermann Hinrichs, Jacobo Diego Sitt, Hans-Jochen Heinze, Oren Shriki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24cd758e8e5c4cb3889124e8b5b8003f
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spelling	oai:doaj.org-article:24cd758e8e5c4cb3889124e8b5b8003f2021-12-02T18:30:57ZMultiscale criticality measures as general-purpose gauges of proper brain function10.1038/s41598-021-93880-82045-2322https://doaj.org/article/24cd758e8e5c4cb3889124e8b5b8003f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93880-8https://doaj.org/toc/2045-2322Abstract The brain is universally regarded as a system for processing information. If so, any behavioral or cognitive dysfunction should lend itself to depiction in terms of information processing deficiencies. Information is characterized by recursive, hierarchical complexity. The brain accommodates this complexity by a hierarchy of large/slow and small/fast spatiotemporal loops of activity. Thus, successful information processing hinges upon tightly regulating the spatiotemporal makeup of activity, to optimally match the underlying multiscale delay structure of such hierarchical networks. Reduced capacity for information processing will then be expressed as deviance from this requisite multiscale character of spatiotemporal activity. This deviance is captured by a general family of multiscale criticality measures (MsCr). MsCr measures reflect the behavior of conventional criticality measures (such as the branching parameter) across temporal scale. We applied MsCr to MEG and EEG data in several telling degraded information processing scenarios. Consistently with our previous modeling work, MsCr measures systematically varied with information processing capacity: MsCr fingerprints showed deviance in the four states of compromised information processing examined in this study, disorders of consciousness, mild cognitive impairment, schizophrenia and even during pre-ictal activity. MsCr measures might thus be able to serve as general gauges of information processing capacity and, therefore, as normative measures of brain health.Tomer FeketeHermann HinrichsJacobo Diego SittHans-Jochen HeinzeOren ShrikiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomer Fekete Hermann Hinrichs Jacobo Diego Sitt Hans-Jochen Heinze Oren Shriki Multiscale criticality measures as general-purpose gauges of proper brain function
description	Abstract The brain is universally regarded as a system for processing information. If so, any behavioral or cognitive dysfunction should lend itself to depiction in terms of information processing deficiencies. Information is characterized by recursive, hierarchical complexity. The brain accommodates this complexity by a hierarchy of large/slow and small/fast spatiotemporal loops of activity. Thus, successful information processing hinges upon tightly regulating the spatiotemporal makeup of activity, to optimally match the underlying multiscale delay structure of such hierarchical networks. Reduced capacity for information processing will then be expressed as deviance from this requisite multiscale character of spatiotemporal activity. This deviance is captured by a general family of multiscale criticality measures (MsCr). MsCr measures reflect the behavior of conventional criticality measures (such as the branching parameter) across temporal scale. We applied MsCr to MEG and EEG data in several telling degraded information processing scenarios. Consistently with our previous modeling work, MsCr measures systematically varied with information processing capacity: MsCr fingerprints showed deviance in the four states of compromised information processing examined in this study, disorders of consciousness, mild cognitive impairment, schizophrenia and even during pre-ictal activity. MsCr measures might thus be able to serve as general gauges of information processing capacity and, therefore, as normative measures of brain health.
format	article
author	Tomer Fekete Hermann Hinrichs Jacobo Diego Sitt Hans-Jochen Heinze Oren Shriki
author_facet	Tomer Fekete Hermann Hinrichs Jacobo Diego Sitt Hans-Jochen Heinze Oren Shriki
author_sort	Tomer Fekete
title	Multiscale criticality measures as general-purpose gauges of proper brain function
title_short	Multiscale criticality measures as general-purpose gauges of proper brain function
title_full	Multiscale criticality measures as general-purpose gauges of proper brain function
title_fullStr	Multiscale criticality measures as general-purpose gauges of proper brain function
title_full_unstemmed	Multiscale criticality measures as general-purpose gauges of proper brain function
title_sort	multiscale criticality measures as general-purpose gauges of proper brain function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24cd758e8e5c4cb3889124e8b5b8003f
work_keys_str_mv	AT tomerfekete multiscalecriticalitymeasuresasgeneralpurposegaugesofproperbrainfunction AT hermannhinrichs multiscalecriticalitymeasuresasgeneralpurposegaugesofproperbrainfunction AT jacobodiegositt multiscalecriticalitymeasuresasgeneralpurposegaugesofproperbrainfunction AT hansjochenheinze multiscalecriticalitymeasuresasgeneralpurposegaugesofproperbrainfunction AT orenshriki multiscalecriticalitymeasuresasgeneralpurposegaugesofproperbrainfunction
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Multiscale criticality measures as general-purpose gauges of proper brain function

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