Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits being more active than the parent compound.

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Autores principales:	Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24ce67f6d8c4465eab7275eeeed39cad
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spelling	oai:doaj.org-article:24ce67f6d8c4465eab7275eeeed39cad2021-12-02T15:35:39ZDevelopment of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E10.1038/s41467-019-10754-42041-1723https://doaj.org/article/24ce67f6d8c4465eab7275eeeed39cad2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10754-4https://doaj.org/toc/2041-1723The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits being more active than the parent compound.Hiroaki ItohKotaro TokumotoTakuya KajiAtmika PaudelSuresh PantheeHiroshi HamamotoKazuhisa SekimizuMasayuki InoueNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroaki Itoh Kotaro Tokumoto Takuya Kaji Atmika Paudel Suresh Panthee Hiroshi Hamamoto Kazuhisa Sekimizu Masayuki Inoue Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
description	The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits being more active than the parent compound.
format	article
author	Hiroaki Itoh Kotaro Tokumoto Takuya Kaji Atmika Paudel Suresh Panthee Hiroshi Hamamoto Kazuhisa Sekimizu Masayuki Inoue
author_facet	Hiroaki Itoh Kotaro Tokumoto Takuya Kaji Atmika Paudel Suresh Panthee Hiroshi Hamamoto Kazuhisa Sekimizu Masayuki Inoue
author_sort	Hiroaki Itoh
title	Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
title_short	Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
title_full	Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
title_fullStr	Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
title_full_unstemmed	Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
title_sort	development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin e
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/24ce67f6d8c4465eab7275eeeed39cad
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Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

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