Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E

The depsipeptide Lysocin E has antibacterial activity against methicillin-resistant Staphylococcus aureus. Here, the authors developed a high-throughput one-bead-on-compound method for the synthesis and screening lysocin E derivatives, with several hits being more active than the parent compound.

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Detalles Bibliográficos
Autores principales: Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/24ce67f6d8c4465eab7275eeeed39cad
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