Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage

Abstract The capability of ordinary surfactants in solubilizing hydrophobic compounds can come to a limit, if the extension of a contaminant is too large. An attractive goal is the development of surfactants which can actively reduce the size of dirt. Because strong Lewis acids are known to catalyze...

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Autores principales:	Marvin L. Frisch, Sebastian Polarz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24cf12cddad0447f9570ff929ba12c1d
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spelling	oai:doaj.org-article:24cf12cddad0447f9570ff929ba12c1d2021-12-02T13:34:46ZMolecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage10.1038/s41598-021-84654-32045-2322https://doaj.org/article/24cf12cddad0447f9570ff929ba12c1d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84654-3https://doaj.org/toc/2045-2322Abstract The capability of ordinary surfactants in solubilizing hydrophobic compounds can come to a limit, if the extension of a contaminant is too large. An attractive goal is the development of surfactants which can actively reduce the size of dirt. Because strong Lewis acids are known to catalyze both bond formation and cleavage, an integration into the surfactant's molecular framework is tempting. End-group functionalized hepta-dentate ligands, which coordinate to metal ions preventing deactivation by hydrolysis over a broad range of pH values while maintaining strong Lewis-acidity, are herein presented. After proof of amphiphilicity and surfactant characteristics, catalytic properties are investigated for different reactions including the cleavage of proteins. The compounds perform better than benchmark catalysts concerning the attack of unreactive amide bonds. A study with two Sc3+ species as the active site, one non-amphiphilic, the other one being surface-active, underlines the positive effect of surfactant properties for boosting catalytic efficiency.Marvin L. FrischSebastian PolarzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marvin L. Frisch Sebastian Polarz Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage
description	Abstract The capability of ordinary surfactants in solubilizing hydrophobic compounds can come to a limit, if the extension of a contaminant is too large. An attractive goal is the development of surfactants which can actively reduce the size of dirt. Because strong Lewis acids are known to catalyze both bond formation and cleavage, an integration into the surfactant's molecular framework is tempting. End-group functionalized hepta-dentate ligands, which coordinate to metal ions preventing deactivation by hydrolysis over a broad range of pH values while maintaining strong Lewis-acidity, are herein presented. After proof of amphiphilicity and surfactant characteristics, catalytic properties are investigated for different reactions including the cleavage of proteins. The compounds perform better than benchmark catalysts concerning the attack of unreactive amide bonds. A study with two Sc3+ species as the active site, one non-amphiphilic, the other one being surface-active, underlines the positive effect of surfactant properties for boosting catalytic efficiency.
format	article
author	Marvin L. Frisch Sebastian Polarz
author_facet	Marvin L. Frisch Sebastian Polarz
author_sort	Marvin L. Frisch
title	Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage
title_short	Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage
title_full	Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage
title_fullStr	Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage
title_full_unstemmed	Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage
title_sort	molecular fusion of surfactant and lewis-acid properties for attacking dirt by catalytic bond cleavage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24cf12cddad0447f9570ff929ba12c1d
work_keys_str_mv	AT marvinlfrisch molecularfusionofsurfactantandlewisacidpropertiesforattackingdirtbycatalyticbondcleavage AT sebastianpolarz molecularfusionofsurfactantandlewisacidpropertiesforattackingdirtbycatalyticbondcleavage
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Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage

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