THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA

Objective: HLA class I and II alleles are shown to be associated with certain diseases. A restricted numbers of alleles were found to be related to alloimmunisation in thalassemia population. The role of human leucocyte antigens in thalassemia is trend topic. In this study, the aim was to evaluate t...

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Autores principales:	Zeynep Karakas, Ayse Erol, Demet Kivanc, Mediha Suleymanoglu, Hayriye Senturk Ciftci, Cigdem Cinar, Serap Karaman, Mustafa Bilici, Aysegul Unuvar, Deniz Tugcu, Gulsah Tanyildiz, Fatma Savran Oguz, Yasin Yilmaz
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/24d1b7ede9bb49f393a738af399c4307
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spelling	oai:doaj.org-article:24d1b7ede9bb49f393a738af399c43072021-11-10T04:33:42ZTHE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA2531-137910.1016/j.htct.2021.10.996https://doaj.org/article/24d1b7ede9bb49f393a738af399c43072021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011433https://doaj.org/toc/2531-1379Objective: HLA class I and II alleles are shown to be associated with certain diseases. A restricted numbers of alleles were found to be related to alloimmunisation in thalassemia population. The role of human leucocyte antigens in thalassemia is trend topic. In this study, the aim was to evaluate the differences in HLA frequencies of beta thalassemia patients comparing with healthy controls. Methodology: The data were collected of 100 patients who were diagnosed with beta thalassemia and 100 healthy controls were included in the study. The low resolution HLA-A, -B, -DRB1, tissue group data were performed Istanbul University, Faculty of Medicine, Medical Biology Department HLA typing laboratory. All data were analyzed retrospectively and their HLA allele frequencies were analyzed by SPSS (v22) program. Results: We found an increased frequency of HLA-B14 (8% versus 2%) and HLA-B52 (17% versus 2%) compared to the control group (p=0.05, OR=4.26; p<0.01, OR=10.03). On the other hand, HLA-B13 frequency was decreased in thalassemia patients (5% versus 13%, p=0.04, OR=0.35). Other HLA-A, -B and -DRB1 allele frequency was similar with healthy controls. Conclusion: Our results showed that HLA-B14 and -B52 allele were associated with beta thalassemia in Turkish population. Several studies found that HLA-DRB115 and DRB111 were associated with alloimmunisation in thalassemia. Other some studies showed DRB107 and chronic infection relation in patients with thalassemia. We found HLA-B certain alleles difference in thalassemia patients which may yield a challenge in finding the matched donor in our population.Zeynep KarakasAyse ErolDemet KivancMediha SuleymanogluHayriye Senturk CiftciCigdem CinarSerap KaramanMustafa BiliciAysegul UnuvarDeniz TugcuGulsah TanyildizFatma Savran OguzYasin YilmazElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S26-S27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Zeynep Karakas Ayse Erol Demet Kivanc Mediha Suleymanoglu Hayriye Senturk Ciftci Cigdem Cinar Serap Karaman Mustafa Bilici Aysegul Unuvar Deniz Tugcu Gulsah Tanyildiz Fatma Savran Oguz Yasin Yilmaz THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA
description	Objective: HLA class I and II alleles are shown to be associated with certain diseases. A restricted numbers of alleles were found to be related to alloimmunisation in thalassemia population. The role of human leucocyte antigens in thalassemia is trend topic. In this study, the aim was to evaluate the differences in HLA frequencies of beta thalassemia patients comparing with healthy controls. Methodology: The data were collected of 100 patients who were diagnosed with beta thalassemia and 100 healthy controls were included in the study. The low resolution HLA-A, -B, -DRB1, tissue group data were performed Istanbul University, Faculty of Medicine, Medical Biology Department HLA typing laboratory. All data were analyzed retrospectively and their HLA allele frequencies were analyzed by SPSS (v22) program. Results: We found an increased frequency of HLA-B14 (8% versus 2%) and HLA-B52 (17% versus 2%) compared to the control group (p=0.05, OR=4.26; p<0.01, OR=10.03). On the other hand, HLA-B13 frequency was decreased in thalassemia patients (5% versus 13%, p=0.04, OR=0.35). Other HLA-A, -B and -DRB1 allele frequency was similar with healthy controls. Conclusion: Our results showed that HLA-B14 and -B52 allele were associated with beta thalassemia in Turkish population. Several studies found that HLA-DRB115 and DRB111 were associated with alloimmunisation in thalassemia. Other some studies showed DRB107 and chronic infection relation in patients with thalassemia. We found HLA-B certain alleles difference in thalassemia patients which may yield a challenge in finding the matched donor in our population.
format	article
author	Zeynep Karakas Ayse Erol Demet Kivanc Mediha Suleymanoglu Hayriye Senturk Ciftci Cigdem Cinar Serap Karaman Mustafa Bilici Aysegul Unuvar Deniz Tugcu Gulsah Tanyildiz Fatma Savran Oguz Yasin Yilmaz
author_facet	Zeynep Karakas Ayse Erol Demet Kivanc Mediha Suleymanoglu Hayriye Senturk Ciftci Cigdem Cinar Serap Karaman Mustafa Bilici Aysegul Unuvar Deniz Tugcu Gulsah Tanyildiz Fatma Savran Oguz Yasin Yilmaz
author_sort	Zeynep Karakas
title	THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA
title_short	THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA
title_full	THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA
title_fullStr	THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA
title_full_unstemmed	THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA
title_sort	frequency of hla-a, b and drb1 alleles in patients with beta thalassemia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/24d1b7ede9bb49f393a738af399c4307
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THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA

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