A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.

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Autores principales: Corina N. D’Alessandro-Gabazza, Tetsu Kobayashi, Taro Yasuma, Masaaki Toda, Heejin Kim, Hajime Fujimoto, Osamu Hataji, Atsuro Takeshita, Kota Nishihama, Tomohito Okano, Yuko Okano, Yoichi Nishii, Atsushi Tomaru, Kentaro Fujiwara, Valeria Fridman D’Alessandro, Ahmed M. Abdel-Hamid, Yudong Ren, Gabriel V. Pereira, Christy L. Wright, Alvaro Hernandez, Christopher J. Fields, Peter M. Yau, Shujie Wang, Akira Mizoguchi, Masayuki Fukumura, Junpei Ohtsuka, Tetsuya Nosaka, Kensuke Kataoka, Yasuhiro Kondoh, Jing Wu, Hirokazu Kawagishi, Yutaka Yano, Roderick I. Mackie, Isaac Cann, Esteban C. Gabazza
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/24d6379d02ba4aa196a47557ce97486e
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Sumario:Idiopathic pulmonary fibrosis is associated with increased abundance of Staphylococcus and Streptococcus in the lungs. Here, the authors identify a Staphylococcus nepalensis-derived peptide, named corisin, to induce apoptosis of lung epithelial cells and exacerbation of pulmonary fibrosis in mice.

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