Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review

Kathryn Speer,1 Dominic Upton,2 Stuart Semple,1,3 Andrew McKune1–4 1Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Canberra, ACT, Australia; 2Faculty of Health, University of Canberra, Canberra, ACT, Australia; 3Research Institute for Sport and Exercis...

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Autores principales:	Speer K, Upton D, Semple S, McKune A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Cytokines C-reactive protein (CRP) chronic disease proinflammation immune system Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/24dfc5386aeb408a8e1ca258199fbb08
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spelling	oai:doaj.org-article:24dfc5386aeb408a8e1ca258199fbb082021-12-02T04:32:41ZSystemic low-grade inflammation in post-traumatic stress disorder: a systematic review1178-7031https://doaj.org/article/24dfc5386aeb408a8e1ca258199fbb082018-03-01T00:00:00Zhttps://www.dovepress.com/systemic-low-grade-inflammation-in-post-traumatic-stress-disorder-a-sy-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Kathryn Speer,1 Dominic Upton,2 Stuart Semple,1,3 Andrew McKune1–4 1Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Canberra, ACT, Australia; 2Faculty of Health, University of Canberra, Canberra, ACT, Australia; 3Research Institute for Sport and Exercise, University of Canberra, Canberra, ACT, Australia; 4Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu Natal, Durban, South Africa Abstract: Studies examining post-traumatic stress disorder (PTSD) have either emphasized a relationship between PTSD and a systemically pro-inflammatory state or identified a link between PTSD and chronic disease. The aim of this study was to evaluate the evidence for a relationship between individuals with PTSD and systemic low-grade inflammation that has been proposed to underlie chronic disease development in this population. The authors conducted a systematic review of the literature (January 2006 to April 2017) in accordance with the PRISMA statement in the following four databases: PubMed, MEDLINE, PsycINFO, and SPORTDiscus with Full Text. The search strategy was limited to articles published in peer-reviewed journals and to human studies. Nine studies measuring systemic inflammation and discussing its role in chronic disease development were selected for inclusion in this review. The association between markers of systemic inflammation and PTSD was evaluated by the measurement of a variety of systemic inflammatory markers including acute-phase proteins, complement proteins, pro- and anti-inflammatory cytokines, natural killer cells, and white blood cells. In general, systemic inflammatory biomarkers were elevated across the studies in the PTSD groups. There is evidence that PTSD is underpinned by the presence of a systemic low-grade inflammatory state. This inflammation may be the mechanism associated with increased risk for chronic disease in the PTSD population. From this, future research should focus on interventions that help to reduce inflammation, such as exercise. Keywords: cytokines, C-reactive protein, CRP, chronic disease, pro-inflammation, immune systemSpeer KUpton DSemple SMcKune ADove Medical PressarticleCytokinesC-reactive protein (CRP)chronic diseaseproinflammationimmune systemPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 111-121 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytokines C-reactive protein (CRP) chronic disease proinflammation immune system Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Cytokines C-reactive protein (CRP) chronic disease proinflammation immune system Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Speer K Upton D Semple S McKune A Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
description	Kathryn Speer,1 Dominic Upton,2 Stuart Semple,1,3 Andrew McKune1–4 1Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Canberra, ACT, Australia; 2Faculty of Health, University of Canberra, Canberra, ACT, Australia; 3Research Institute for Sport and Exercise, University of Canberra, Canberra, ACT, Australia; 4Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu Natal, Durban, South Africa Abstract: Studies examining post-traumatic stress disorder (PTSD) have either emphasized a relationship between PTSD and a systemically pro-inflammatory state or identified a link between PTSD and chronic disease. The aim of this study was to evaluate the evidence for a relationship between individuals with PTSD and systemic low-grade inflammation that has been proposed to underlie chronic disease development in this population. The authors conducted a systematic review of the literature (January 2006 to April 2017) in accordance with the PRISMA statement in the following four databases: PubMed, MEDLINE, PsycINFO, and SPORTDiscus with Full Text. The search strategy was limited to articles published in peer-reviewed journals and to human studies. Nine studies measuring systemic inflammation and discussing its role in chronic disease development were selected for inclusion in this review. The association between markers of systemic inflammation and PTSD was evaluated by the measurement of a variety of systemic inflammatory markers including acute-phase proteins, complement proteins, pro- and anti-inflammatory cytokines, natural killer cells, and white blood cells. In general, systemic inflammatory biomarkers were elevated across the studies in the PTSD groups. There is evidence that PTSD is underpinned by the presence of a systemic low-grade inflammatory state. This inflammation may be the mechanism associated with increased risk for chronic disease in the PTSD population. From this, future research should focus on interventions that help to reduce inflammation, such as exercise. Keywords: cytokines, C-reactive protein, CRP, chronic disease, pro-inflammation, immune system
format	article
author	Speer K Upton D Semple S McKune A
author_facet	Speer K Upton D Semple S McKune A
author_sort	Speer K
title	Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
title_short	Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
title_full	Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
title_fullStr	Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
title_full_unstemmed	Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
title_sort	systemic low-grade inflammation in post-traumatic stress disorder: a systematic review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/24dfc5386aeb408a8e1ca258199fbb08
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Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review

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