Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking

Abstract The ability to move and maintain posture is critically dependent on motion and orientation information provided by the vestibular system. When this system delivers noisy or erred information it can, in some cases, be attenuated through habituation. Here we investigate whether multiple mecha...

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Autores principales:	Kelci B. Hannan, Makina K. Todd, Nicole J. Pearson, Patrick A. Forbes, Christopher J. Dakin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24e1f2c9da4d449394827a3187c99b44
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spelling	oai:doaj.org-article:24e1f2c9da4d449394827a3187c99b442021-12-02T14:27:59ZVestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking10.1038/s41598-021-87485-42045-2322https://doaj.org/article/24e1f2c9da4d449394827a3187c99b442021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87485-4https://doaj.org/toc/2045-2322Abstract The ability to move and maintain posture is critically dependent on motion and orientation information provided by the vestibular system. When this system delivers noisy or erred information it can, in some cases, be attenuated through habituation. Here we investigate whether multiple mechanisms of attenuation act to decrease vestibular gain due to noise added using supra-threshold random-waveform galvanic vestibular stimulation (GVS). Forty-five participants completed one of three conditions. Each condition consisted of two 4-min standing periods with stimulation surrounding a 1-h period of either walking with stimulation, walking without stimulation, or sitting quietly. An instrumented treadmill recorded horizontal forces at the feet during standing and walking. We quantified response attenuation to GVS by comparing vestibular stimulus-horizontal force gain between conditions. First stimulus exposure caused an 18% decrease in gain during the first 40 s of standing. Attenuation recommenced only when subjects walked with stimulation, resulting in a 38% decrease in gain over 60 min that did not transfer to standing following walking. The disparity in attenuation dynamics and absent carry over between standing and walking suggests that two mechanisms of attenuation, one associated with first exposure to the stimulus and another that is task specific, may act to decrease vestibulomotor gain.Kelci B. HannanMakina K. ToddNicole J. PearsonPatrick A. ForbesChristopher J. DakinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kelci B. Hannan Makina K. Todd Nicole J. Pearson Patrick A. Forbes Christopher J. Dakin Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
description	Abstract The ability to move and maintain posture is critically dependent on motion and orientation information provided by the vestibular system. When this system delivers noisy or erred information it can, in some cases, be attenuated through habituation. Here we investigate whether multiple mechanisms of attenuation act to decrease vestibular gain due to noise added using supra-threshold random-waveform galvanic vestibular stimulation (GVS). Forty-five participants completed one of three conditions. Each condition consisted of two 4-min standing periods with stimulation surrounding a 1-h period of either walking with stimulation, walking without stimulation, or sitting quietly. An instrumented treadmill recorded horizontal forces at the feet during standing and walking. We quantified response attenuation to GVS by comparing vestibular stimulus-horizontal force gain between conditions. First stimulus exposure caused an 18% decrease in gain during the first 40 s of standing. Attenuation recommenced only when subjects walked with stimulation, resulting in a 38% decrease in gain over 60 min that did not transfer to standing following walking. The disparity in attenuation dynamics and absent carry over between standing and walking suggests that two mechanisms of attenuation, one associated with first exposure to the stimulus and another that is task specific, may act to decrease vestibulomotor gain.
format	article
author	Kelci B. Hannan Makina K. Todd Nicole J. Pearson Patrick A. Forbes Christopher J. Dakin
author_facet	Kelci B. Hannan Makina K. Todd Nicole J. Pearson Patrick A. Forbes Christopher J. Dakin
author_sort	Kelci B. Hannan
title	Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
title_short	Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
title_full	Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
title_fullStr	Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
title_full_unstemmed	Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
title_sort	vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24e1f2c9da4d449394827a3187c99b44
work_keys_str_mv	AT kelcibhannan vestibularattenuationtorandomwaveformgalvanicvestibularstimulationduringstandingandtreadmillwalking AT makinaktodd vestibularattenuationtorandomwaveformgalvanicvestibularstimulationduringstandingandtreadmillwalking AT nicolejpearson vestibularattenuationtorandomwaveformgalvanicvestibularstimulationduringstandingandtreadmillwalking AT patrickaforbes vestibularattenuationtorandomwaveformgalvanicvestibularstimulationduringstandingandtreadmillwalking AT christopherjdakin vestibularattenuationtorandomwaveformgalvanicvestibularstimulationduringstandingandtreadmillwalking
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Vestibular attenuation to random-waveform galvanic vestibular stimulation during standing and treadmill walking

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