Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

Wnt signaling is known to regulate the formation of the blood-brain barrier. Here Hübner et al. dissect the underlying mechanisms using high resolution live imaging in zebrafish, and find that Wnt regulates anastomosis of angiogenic sprouts in the brain by counteracting sphingosine-1-phosphate recep...

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Autores principales:	Kathleen Hübner, Pauline Cabochette, Rodrigo Diéguez-Hurtado, Cora Wiesner, Yuki Wakayama, Kathrin S. Grassme, Marvin Hubert, Stefan Guenther, Heinz-Georg Belting, Markus Affolter, Ralf H. Adams, Benoit Vanhollebeke, Wiebke Herzog
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24e4c6a49599424898a125c7c9be3b6f
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spelling	oai:doaj.org-article:24e4c6a49599424898a125c7c9be3b6f2021-12-02T16:49:53ZWnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling10.1038/s41467-018-07302-x2041-1723https://doaj.org/article/24e4c6a49599424898a125c7c9be3b6f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07302-xhttps://doaj.org/toc/2041-1723Wnt signaling is known to regulate the formation of the blood-brain barrier. Here Hübner et al. dissect the underlying mechanisms using high resolution live imaging in zebrafish, and find that Wnt regulates anastomosis of angiogenic sprouts in the brain by counteracting sphingosine-1-phosphate receptor signaling.Kathleen HübnerPauline CabochetteRodrigo Diéguez-HurtadoCora WiesnerYuki WakayamaKathrin S. GrassmeMarvin HubertStefan GuentherHeinz-Georg BeltingMarkus AffolterRalf H. AdamsBenoit VanhollebekeWiebke HerzogNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathleen Hübner Pauline Cabochette Rodrigo Diéguez-Hurtado Cora Wiesner Yuki Wakayama Kathrin S. Grassme Marvin Hubert Stefan Guenther Heinz-Georg Belting Markus Affolter Ralf H. Adams Benoit Vanhollebeke Wiebke Herzog Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
description	Wnt signaling is known to regulate the formation of the blood-brain barrier. Here Hübner et al. dissect the underlying mechanisms using high resolution live imaging in zebrafish, and find that Wnt regulates anastomosis of angiogenic sprouts in the brain by counteracting sphingosine-1-phosphate receptor signaling.
format	article
author	Kathleen Hübner Pauline Cabochette Rodrigo Diéguez-Hurtado Cora Wiesner Yuki Wakayama Kathrin S. Grassme Marvin Hubert Stefan Guenther Heinz-Georg Belting Markus Affolter Ralf H. Adams Benoit Vanhollebeke Wiebke Herzog
author_facet	Kathleen Hübner Pauline Cabochette Rodrigo Diéguez-Hurtado Cora Wiesner Yuki Wakayama Kathrin S. Grassme Marvin Hubert Stefan Guenther Heinz-Georg Belting Markus Affolter Ralf H. Adams Benoit Vanhollebeke Wiebke Herzog
author_sort	Kathleen Hübner
title	Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
title_short	Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
title_full	Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
title_fullStr	Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
title_full_unstemmed	Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling
title_sort	wnt/β-catenin signaling regulates ve-cadherin-mediated anastomosis of brain capillaries by counteracting s1pr1 signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/24e4c6a49599424898a125c7c9be3b6f
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Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

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