Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Ghrelin is a gastric peptide hormone and its acylation is required for binding to and activation of the ghrelin receptor in the brain, which initiates appetite. Here, the authors present cryo-EM structures of the Gq-coupled ghrelin receptor bound to ghrelin and the synthetic agonist GHRP-6 and they...

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Autores principales:	Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H. Eric Xu, Xin Xie, Yi Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24e534c788b94b1ebb4dd46fb7bb7dbf
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spelling	oai:doaj.org-article:24e534c788b94b1ebb4dd46fb7bb7dbf2021-12-02T18:00:08ZMolecular recognition of an acyl-peptide hormone and activation of ghrelin receptor10.1038/s41467-021-25364-22041-1723https://doaj.org/article/24e534c788b94b1ebb4dd46fb7bb7dbf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25364-2https://doaj.org/toc/2041-1723Ghrelin is a gastric peptide hormone and its acylation is required for binding to and activation of the ghrelin receptor in the brain, which initiates appetite. Here, the authors present cryo-EM structures of the Gq-coupled ghrelin receptor bound to ghrelin and the synthetic agonist GHRP-6 and they describe how the acylated peptide hormone is recognised by the receptor, which is of interest for drug design.Yue WangShimeng GuoYouwen ZhuangYing YunPeiyu XuXinheng HeJia GuoWanchao YinH. Eric XuXin XieYi JiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue Wang Shimeng Guo Youwen Zhuang Ying Yun Peiyu Xu Xinheng He Jia Guo Wanchao Yin H. Eric Xu Xin Xie Yi Jiang Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
description	Ghrelin is a gastric peptide hormone and its acylation is required for binding to and activation of the ghrelin receptor in the brain, which initiates appetite. Here, the authors present cryo-EM structures of the Gq-coupled ghrelin receptor bound to ghrelin and the synthetic agonist GHRP-6 and they describe how the acylated peptide hormone is recognised by the receptor, which is of interest for drug design.
format	article
author	Yue Wang Shimeng Guo Youwen Zhuang Ying Yun Peiyu Xu Xinheng He Jia Guo Wanchao Yin H. Eric Xu Xin Xie Yi Jiang
author_facet	Yue Wang Shimeng Guo Youwen Zhuang Ying Yun Peiyu Xu Xinheng He Jia Guo Wanchao Yin H. Eric Xu Xin Xie Yi Jiang
author_sort	Yue Wang
title	Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
title_short	Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
title_full	Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
title_fullStr	Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
title_full_unstemmed	Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
title_sort	molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24e534c788b94b1ebb4dd46fb7bb7dbf
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Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

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