Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls

BACKGROUND AND OBJECTIVE: Brucellosis is a zoonotic disease in the world. It has been shown that host resistance to brucella bacteria depends on Th1 response, whereas Th2 response is involved in the severity of the disease. It is suggested that CD26 and CD30 are surface molecules expressed on activa...

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Autores principales:	AR Rafiei, MR Hasanjani Roushan, Z Hoseini Khah, A . Ajami, Z Orouji
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	brucellosis cd26 cd30 Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/24e988af86e7441681ddf65483536a4d
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id	oai:doaj.org-article:24e988af86e7441681ddf65483536a4d
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spelling	oai:doaj.org-article:24e988af86e7441681ddf65483536a4d2021-11-10T09:02:43ZComparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls1561-41072251-7170https://doaj.org/article/24e988af86e7441681ddf65483536a4d2009-06-01T00:00:00Zhttp://jbums.org/article-1-3129-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Brucellosis is a zoonotic disease in the world. It has been shown that host resistance to brucella bacteria depends on Th1 response, whereas Th2 response is involved in the severity of the disease. It is suggested that CD26 and CD30 are surface molecules expressed on activated Th1 and Th2 cells, respectively. The aim of the present study was to determine the levels of soluble (s) CD26 and CD30 molecules in sera of brucellosis and healthy controls.METHODS: The study included 90 brucellosis patients and 70 healthy controls. Brucellosis was diagnosed base on clinical findings, microbiologic or/and serologic findings. The levels of sCD26 and sCD30 were determined by a sandwich enzyme-linked immunosorbent assay in sera of study population.FINDINGS: Serum levels of sCD26 were 847.07±249.7 and 504.97±165.6 ng/ml in brucellosis and controls, respectively, which shown a significant difference (p<0.0001). Meanwhile, there was no significant difference in sCD30 levels between brucellosis and controls (51.33±35.9 and 42.75±20.87 IU/ml).CONCLUSION: These findings indicate that assessment of sCD26 and sCD30 levels are a valuable and quick method for evaluating immune response to brucellosis.AR Rafiei,MR Hasanjani RoushanZ Hoseini KhahA . AjamiZ OroujiBabol University of Medical Sciencesarticlebrucellosiscd26cd30MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 2, Pp 54-60 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	brucellosis cd26 cd30 Medicine R Medicine (General) R5-920
spellingShingle	brucellosis cd26 cd30 Medicine R Medicine (General) R5-920 AR Rafiei, MR Hasanjani Roushan Z Hoseini Khah A . Ajami Z Orouji Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls
description	BACKGROUND AND OBJECTIVE: Brucellosis is a zoonotic disease in the world. It has been shown that host resistance to brucella bacteria depends on Th1 response, whereas Th2 response is involved in the severity of the disease. It is suggested that CD26 and CD30 are surface molecules expressed on activated Th1 and Th2 cells, respectively. The aim of the present study was to determine the levels of soluble (s) CD26 and CD30 molecules in sera of brucellosis and healthy controls.METHODS: The study included 90 brucellosis patients and 70 healthy controls. Brucellosis was diagnosed base on clinical findings, microbiologic or/and serologic findings. The levels of sCD26 and sCD30 were determined by a sandwich enzyme-linked immunosorbent assay in sera of study population.FINDINGS: Serum levels of sCD26 were 847.07±249.7 and 504.97±165.6 ng/ml in brucellosis and controls, respectively, which shown a significant difference (p<0.0001). Meanwhile, there was no significant difference in sCD30 levels between brucellosis and controls (51.33±35.9 and 42.75±20.87 IU/ml).CONCLUSION: These findings indicate that assessment of sCD26 and sCD30 levels are a valuable and quick method for evaluating immune response to brucellosis.
format	article
author	AR Rafiei, MR Hasanjani Roushan Z Hoseini Khah A . Ajami Z Orouji
author_facet	AR Rafiei, MR Hasanjani Roushan Z Hoseini Khah A . Ajami Z Orouji
author_sort	AR Rafiei,
title	Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls
title_short	Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls
title_full	Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls
title_fullStr	Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls
title_full_unstemmed	Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls
title_sort	comparison of serum levels of soluble cd26 and cd30 in patients with brucellosis and controls
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/24e988af86e7441681ddf65483536a4d
work_keys_str_mv	AT arrafiei comparisonofserumlevelsofsolublecd26andcd30inpatientswithbrucellosisandcontrols AT mrhasanjaniroushan comparisonofserumlevelsofsolublecd26andcd30inpatientswithbrucellosisandcontrols AT zhoseinikhah comparisonofserumlevelsofsolublecd26andcd30inpatientswithbrucellosisandcontrols AT aajami comparisonofserumlevelsofsolublecd26andcd30inpatientswithbrucellosisandcontrols AT zorouji comparisonofserumlevelsofsolublecd26andcd30inpatientswithbrucellosisandcontrols
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Comparison of Serum Levels of Soluble CD26 and CD30 in Patients with Brucellosis and Controls

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