Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

Endothelial cells (EC) are known to contribute to haematopoietic stem cell (HSC) maintenance in the bone marrow (BM). Here the authors demonstrate that arterial ECs can be distinguished from sinusoidal ECs by podoplanin and Sca-1 expression, and that specifically arterial, but not sinusoidal ECs mai...

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Auteurs principaux:	Chunliang Xu, Xin Gao, Qiaozhi Wei, Fumio Nakahara, Samuel E. Zimmerman, Jessica Mar, Paul S. Frenette
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/24eca0c01e8948c9b67d63080d2714e3
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id	oai:doaj.org-article:24eca0c01e8948c9b67d63080d2714e3
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spelling	oai:doaj.org-article:24eca0c01e8948c9b67d63080d2714e32021-12-02T16:49:18ZStem cell factor is selectively secreted by arterial endothelial cells in bone marrow10.1038/s41467-018-04726-32041-1723https://doaj.org/article/24eca0c01e8948c9b67d63080d2714e32018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04726-3https://doaj.org/toc/2041-1723Endothelial cells (EC) are known to contribute to haematopoietic stem cell (HSC) maintenance in the bone marrow (BM). Here the authors demonstrate that arterial ECs can be distinguished from sinusoidal ECs by podoplanin and Sca-1 expression, and that specifically arterial, but not sinusoidal ECs maintain HSCs by secreting SCF.Chunliang XuXin GaoQiaozhi WeiFumio NakaharaSamuel E. ZimmermanJessica MarPaul S. FrenetteNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunliang Xu Xin Gao Qiaozhi Wei Fumio Nakahara Samuel E. Zimmerman Jessica Mar Paul S. Frenette Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
description	Endothelial cells (EC) are known to contribute to haematopoietic stem cell (HSC) maintenance in the bone marrow (BM). Here the authors demonstrate that arterial ECs can be distinguished from sinusoidal ECs by podoplanin and Sca-1 expression, and that specifically arterial, but not sinusoidal ECs maintain HSCs by secreting SCF.
format	article
author	Chunliang Xu Xin Gao Qiaozhi Wei Fumio Nakahara Samuel E. Zimmerman Jessica Mar Paul S. Frenette
author_facet	Chunliang Xu Xin Gao Qiaozhi Wei Fumio Nakahara Samuel E. Zimmerman Jessica Mar Paul S. Frenette
author_sort	Chunliang Xu
title	Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
title_short	Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
title_full	Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
title_fullStr	Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
title_full_unstemmed	Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
title_sort	stem cell factor is selectively secreted by arterial endothelial cells in bone marrow
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/24eca0c01e8948c9b67d63080d2714e3
work_keys_str_mv	AT chunliangxu stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow AT xingao stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow AT qiaozhiwei stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow AT fumionakahara stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow AT samuelezimmerman stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow AT jessicamar stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow AT paulsfrenette stemcellfactorisselectivelysecretedbyarterialendothelialcellsinbonemarrow
_version_	1718383322812383232

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

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