rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin

The role of the nucleolus in cell fate is not well known. Here the authors show nucleolar integrity maintained by rRNA-mediated liquid-liquid phase separation and 3D chromatin structure of perinucleolar heterochromatin regulates the fate transition of mouse embryonic stem cells to 2 cell-stage embry...

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Autores principales:	Hua Yu, Zhen Sun, Tianyu Tan, Hongru Pan, Jing Zhao, Ling Zhang, Jiayu Chen, Anhua Lei, Yuqing Zhu, Lang Chen, Yuyan Xu, Yaxin Liu, Ming Chen, Jinghao Sheng, Zhengping Xu, Pengxu Qian, Cheng Li, Shaorong Gao, George Q. Daley, Jin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24ed821a05d7423a843829e3bb8e0f2c
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spelling	oai:doaj.org-article:24ed821a05d7423a843829e3bb8e0f2c2021-11-14T12:35:27ZrRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin10.1038/s41467-021-26576-22041-1723https://doaj.org/article/24ed821a05d7423a843829e3bb8e0f2c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26576-2https://doaj.org/toc/2041-1723The role of the nucleolus in cell fate is not well known. Here the authors show nucleolar integrity maintained by rRNA-mediated liquid-liquid phase separation and 3D chromatin structure of perinucleolar heterochromatin regulates the fate transition of mouse embryonic stem cells to 2 cell-stage embryo-like cells, and that rRNA biogenesis regulates the 2-cell-to-4-cell transition of development.Hua YuZhen SunTianyu TanHongru PanJing ZhaoLing ZhangJiayu ChenAnhua LeiYuqing ZhuLang ChenYuyan XuYaxin LiuMing ChenJinghao ShengZhengping XuPengxu QianCheng LiShaorong GaoGeorge Q. DaleyJin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hua Yu Zhen Sun Tianyu Tan Hongru Pan Jing Zhao Ling Zhang Jiayu Chen Anhua Lei Yuqing Zhu Lang Chen Yuyan Xu Yaxin Liu Ming Chen Jinghao Sheng Zhengping Xu Pengxu Qian Cheng Li Shaorong Gao George Q. Daley Jin Zhang rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
description	The role of the nucleolus in cell fate is not well known. Here the authors show nucleolar integrity maintained by rRNA-mediated liquid-liquid phase separation and 3D chromatin structure of perinucleolar heterochromatin regulates the fate transition of mouse embryonic stem cells to 2 cell-stage embryo-like cells, and that rRNA biogenesis regulates the 2-cell-to-4-cell transition of development.
format	article
author	Hua Yu Zhen Sun Tianyu Tan Hongru Pan Jing Zhao Ling Zhang Jiayu Chen Anhua Lei Yuqing Zhu Lang Chen Yuyan Xu Yaxin Liu Ming Chen Jinghao Sheng Zhengping Xu Pengxu Qian Cheng Li Shaorong Gao George Q. Daley Jin Zhang
author_facet	Hua Yu Zhen Sun Tianyu Tan Hongru Pan Jing Zhao Ling Zhang Jiayu Chen Anhua Lei Yuqing Zhu Lang Chen Yuyan Xu Yaxin Liu Ming Chen Jinghao Sheng Zhengping Xu Pengxu Qian Cheng Li Shaorong Gao George Q. Daley Jin Zhang
author_sort	Hua Yu
title	rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
title_short	rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
title_full	rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
title_fullStr	rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
title_full_unstemmed	rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
title_sort	rrna biogenesis regulates mouse 2c-like state by 3d structure reorganization of peri-nucleolar heterochromatin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24ed821a05d7423a843829e3bb8e0f2c
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rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin

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