Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review

Probiotics have potential clinical effects for treating and preventing osteoporosis. Meanwhile, isoflavones have attracted much attention due to their ability to prevent postmenopausal symptoms. Research has established that probiotics and isoflavones can regulate hormones, immune cells, and the gas...

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Autores principales:	Iskandar Azmy Harahap, Joanna Suliburska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	probiotics isoflavones calcium status bone health osteoporosis Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/24edefc96dfb4b07a09ff8c58ae3f98e
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spelling	oai:doaj.org-article:24edefc96dfb4b07a09ff8c58ae3f98e2021-11-25T17:34:10ZProbiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review10.3390/foods101126852304-8158https://doaj.org/article/24edefc96dfb4b07a09ff8c58ae3f98e2021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2685https://doaj.org/toc/2304-8158Probiotics have potential clinical effects for treating and preventing osteoporosis. Meanwhile, isoflavones have attracted much attention due to their ability to prevent postmenopausal symptoms. Research has established that probiotics and isoflavones can regulate hormones, immune cells, and the gastrointestinal system, acting as links in the gut–bone axis. However, combining the effects of probiotics and isoflavones on calcium status and bone health is a more novel and a still-evolving research area. <i>Lactobacillus</i> and <i>Bifidobacterium</i> are the foremost strains that influence bone health to a significant extent. Among the isoflavones, daidzein, genistein, and the metabolites of genistein (such as equol) stimulate bone formation. It can be concluded that probiotics and isoflavones promote bone health by regulating calcium uptake, gut microbiota, and various metabolic pathways that are associated with osteoblast activity and bone formation. Nevertheless, further experiments of probiotics and isoflavones are still necessary to confirm the association between calcium bioavailability and bone health.Iskandar Azmy HarahapJoanna SuliburskaMDPI AGarticleprobioticsisoflavonescalcium statusbone healthosteoporosisChemical technologyTP1-1185ENFoods, Vol 10, Iss 2685, p 2685 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	probiotics isoflavones calcium status bone health osteoporosis Chemical technology TP1-1185
spellingShingle	probiotics isoflavones calcium status bone health osteoporosis Chemical technology TP1-1185 Iskandar Azmy Harahap Joanna Suliburska Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review
description	Probiotics have potential clinical effects for treating and preventing osteoporosis. Meanwhile, isoflavones have attracted much attention due to their ability to prevent postmenopausal symptoms. Research has established that probiotics and isoflavones can regulate hormones, immune cells, and the gastrointestinal system, acting as links in the gut–bone axis. However, combining the effects of probiotics and isoflavones on calcium status and bone health is a more novel and a still-evolving research area. <i>Lactobacillus</i> and <i>Bifidobacterium</i> are the foremost strains that influence bone health to a significant extent. Among the isoflavones, daidzein, genistein, and the metabolites of genistein (such as equol) stimulate bone formation. It can be concluded that probiotics and isoflavones promote bone health by regulating calcium uptake, gut microbiota, and various metabolic pathways that are associated with osteoblast activity and bone formation. Nevertheless, further experiments of probiotics and isoflavones are still necessary to confirm the association between calcium bioavailability and bone health.
format	article
author	Iskandar Azmy Harahap Joanna Suliburska
author_facet	Iskandar Azmy Harahap Joanna Suliburska
author_sort	Iskandar Azmy Harahap
title	Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review
title_short	Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review
title_full	Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review
title_fullStr	Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review
title_full_unstemmed	Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review
title_sort	probiotics and isoflavones as a promising therapeutic for calcium status and bone health: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/24edefc96dfb4b07a09ff8c58ae3f98e
work_keys_str_mv	AT iskandarazmyharahap probioticsandisoflavonesasapromisingtherapeuticforcalciumstatusandbonehealthanarrativereview AT joannasuliburska probioticsandisoflavonesasapromisingtherapeuticforcalciumstatusandbonehealthanarrativereview
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Probiotics and Isoflavones as a Promising Therapeutic for Calcium Status and Bone Health: A Narrative Review

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