Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium

Pneumococci produce a carbohydrate capsule that protects them against components of the host immune system but sensitizes them to host antimicrobial peptides. Here, Kietzman et al.show that pneumococci respond to antimicrobial peptides by capsule shedding, which requires the main autolysin LytA.

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Autores principales:	Colin C. Kietzman, Geli Gao, Beth Mann, Lance Myers, Elaine I. Tuomanen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24f047e9b6fb4ce2aae6539763ce00f0
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spelling	oai:doaj.org-article:24f047e9b6fb4ce2aae6539763ce00f02021-12-02T16:49:25ZDynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium10.1038/ncomms108592041-1723https://doaj.org/article/24f047e9b6fb4ce2aae6539763ce00f02016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10859https://doaj.org/toc/2041-1723Pneumococci produce a carbohydrate capsule that protects them against components of the host immune system but sensitizes them to host antimicrobial peptides. Here, Kietzman et al.show that pneumococci respond to antimicrobial peptides by capsule shedding, which requires the main autolysin LytA.Colin C. KietzmanGeli GaoBeth MannLance MyersElaine I. TuomanenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Colin C. Kietzman Geli Gao Beth Mann Lance Myers Elaine I. Tuomanen Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium
description	Pneumococci produce a carbohydrate capsule that protects them against components of the host immune system but sensitizes them to host antimicrobial peptides. Here, Kietzman et al.show that pneumococci respond to antimicrobial peptides by capsule shedding, which requires the main autolysin LytA.
format	article
author	Colin C. Kietzman Geli Gao Beth Mann Lance Myers Elaine I. Tuomanen
author_facet	Colin C. Kietzman Geli Gao Beth Mann Lance Myers Elaine I. Tuomanen
author_sort	Colin C. Kietzman
title	Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium
title_short	Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium
title_full	Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium
title_fullStr	Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium
title_full_unstemmed	Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium
title_sort	dynamic capsule restructuring by the main pneumococcal autolysin lyta in response to the epithelium
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/24f047e9b6fb4ce2aae6539763ce00f0
work_keys_str_mv	AT colinckietzman dynamiccapsulerestructuringbythemainpneumococcalautolysinlytainresponsetotheepithelium AT geligao dynamiccapsulerestructuringbythemainpneumococcalautolysinlytainresponsetotheepithelium AT bethmann dynamiccapsulerestructuringbythemainpneumococcalautolysinlytainresponsetotheepithelium AT lancemyers dynamiccapsulerestructuringbythemainpneumococcalautolysinlytainresponsetotheepithelium AT elaineituomanen dynamiccapsulerestructuringbythemainpneumococcalautolysinlytainresponsetotheepithelium
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Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium

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