Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model

The data described in this article presents the toxicity of rotenone and the neuroprotective effect of Yashtimadhu choorna (powder) in an in vitro Parkinson's disease model [1]. Yashtimadhu choorna is prepared from the roots of Glycyrrhiza glabra L., commonly known as licorice/ liquorice. The e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gayathree Karthikkeyan, Ashwini Prabhu, Ravishankar Pervaje, Sameera Krishna Pervaje, Prashant Kumar Modi, Thottethodi Subrahmanya Keshava Prasad
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neurodegeneration Complementary and alternative medicine Ayurveda Actionable molecules Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/24f285a1523d44d1b6bc157b0ff1c2f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:24f285a1523d44d1b6bc157b0ff1c2f3
record_format	dspace
spelling	oai:doaj.org-article:24f285a1523d44d1b6bc157b0ff1c2f32021-11-12T04:37:31ZData on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model2352-340910.1016/j.dib.2021.107535https://doaj.org/article/24f285a1523d44d1b6bc157b0ff1c2f32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352340921008118https://doaj.org/toc/2352-3409The data described in this article presents the toxicity of rotenone and the neuroprotective effect of Yashtimadhu choorna (powder) in an in vitro Parkinson's disease model [1]. Yashtimadhu choorna is prepared from the roots of Glycyrrhiza glabra L., commonly known as licorice/ liquorice. The effects of rotenone and Yashtimadhu was assessed using cellular and molecular assays such as cell cytotoxicity assay, live-dead cell staining assay, cell cycle analysis, and western blotting. Protein-protein interaction was studied using ANAT plug-in in Cytoscape. Rotenone displayed time and dose-dependent toxicity, as evidenced by cell cytotoxicity assay and live-dead cell staining assay. Yashtimadhu showed no toxicity and prevented rotenone-induced toxicity. Rotenone and Yashtimadhu displayed differential control on the cell cycle. The Protein-interaction network showed the proteins interacting with ERK-1/2 and the pathways regulated by these interactions. The pathways regulated were primarily involved in cellular oxidative stress and apoptosis response. The data described here will enable the extent of cellular toxicity as a result of rotenone treatment and the neuroprotection conferred by Yashtimadhu choorna. This will enable understanding and exploring the effect of traditional and complementary medicine and aiding the identification of molecular targets to confer neuroprotection in Parkinson's disease.Gayathree KarthikkeyanAshwini PrabhuRavishankar PervajeSameera Krishna PervajePrashant Kumar ModiThottethodi Subrahmanya Keshava PrasadElsevierarticleNeurodegenerationComplementary and alternative medicineAyurvedaActionable moleculesComputer applications to medicine. Medical informaticsR858-859.7Science (General)Q1-390ENData in Brief, Vol 39, Iss , Pp 107535- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurodegeneration Complementary and alternative medicine Ayurveda Actionable molecules Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
spellingShingle	Neurodegeneration Complementary and alternative medicine Ayurveda Actionable molecules Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390 Gayathree Karthikkeyan Ashwini Prabhu Ravishankar Pervaje Sameera Krishna Pervaje Prashant Kumar Modi Thottethodi Subrahmanya Keshava Prasad Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model
description	The data described in this article presents the toxicity of rotenone and the neuroprotective effect of Yashtimadhu choorna (powder) in an in vitro Parkinson's disease model [1]. Yashtimadhu choorna is prepared from the roots of Glycyrrhiza glabra L., commonly known as licorice/ liquorice. The effects of rotenone and Yashtimadhu was assessed using cellular and molecular assays such as cell cytotoxicity assay, live-dead cell staining assay, cell cycle analysis, and western blotting. Protein-protein interaction was studied using ANAT plug-in in Cytoscape. Rotenone displayed time and dose-dependent toxicity, as evidenced by cell cytotoxicity assay and live-dead cell staining assay. Yashtimadhu showed no toxicity and prevented rotenone-induced toxicity. Rotenone and Yashtimadhu displayed differential control on the cell cycle. The Protein-interaction network showed the proteins interacting with ERK-1/2 and the pathways regulated by these interactions. The pathways regulated were primarily involved in cellular oxidative stress and apoptosis response. The data described here will enable the extent of cellular toxicity as a result of rotenone treatment and the neuroprotection conferred by Yashtimadhu choorna. This will enable understanding and exploring the effect of traditional and complementary medicine and aiding the identification of molecular targets to confer neuroprotection in Parkinson's disease.
format	article
author	Gayathree Karthikkeyan Ashwini Prabhu Ravishankar Pervaje Sameera Krishna Pervaje Prashant Kumar Modi Thottethodi Subrahmanya Keshava Prasad
author_facet	Gayathree Karthikkeyan Ashwini Prabhu Ravishankar Pervaje Sameera Krishna Pervaje Prashant Kumar Modi Thottethodi Subrahmanya Keshava Prasad
author_sort	Gayathree Karthikkeyan
title	Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model
title_short	Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model
title_full	Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model
title_fullStr	Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model
title_full_unstemmed	Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model
title_sort	data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by yashtimadhu (glycyrrhiza glabra l.) in an in vitro parkinson's disease model
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/24f285a1523d44d1b6bc157b0ff1c2f3
work_keys_str_mv	AT gayathreekarthikkeyan dataondosedependentcytotoxicityofrotenoneandneuroprotectionconferredbyyashtimadhuglycyrrhizaglabralinaninvitroparkinsonsdiseasemodel AT ashwiniprabhu dataondosedependentcytotoxicityofrotenoneandneuroprotectionconferredbyyashtimadhuglycyrrhizaglabralinaninvitroparkinsonsdiseasemodel AT ravishankarpervaje dataondosedependentcytotoxicityofrotenoneandneuroprotectionconferredbyyashtimadhuglycyrrhizaglabralinaninvitroparkinsonsdiseasemodel AT sameerakrishnapervaje dataondosedependentcytotoxicityofrotenoneandneuroprotectionconferredbyyashtimadhuglycyrrhizaglabralinaninvitroparkinsonsdiseasemodel AT prashantkumarmodi dataondosedependentcytotoxicityofrotenoneandneuroprotectionconferredbyyashtimadhuglycyrrhizaglabralinaninvitroparkinsonsdiseasemodel AT thottethodisubrahmanyakeshavaprasad dataondosedependentcytotoxicityofrotenoneandneuroprotectionconferredbyyashtimadhuglycyrrhizaglabralinaninvitroparkinsonsdiseasemodel
_version_	1718431219303055360

Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model

Ejemplares similares