Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined the...
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2021
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oai:doaj.org-article:24f95c4684064d02b96f11579314de8f2021-11-25T16:29:54ZAnti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease10.3390/antiox101118552076-3921https://doaj.org/article/24f95c4684064d02b96f11579314de8f2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1855https://doaj.org/toc/2076-3921Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined the neuroprotective effects of the barbiturate derivative, MHY2699 [5-(4-hydroxy 3,5-dimethoxybenzyl)-2 thioxodihydropyrimidine-4,6(1H,5H)-dione] in a mouse model of PD. MHY2699 ameliorated MPP⁺-induced astrocyte activation and ROS production in primary astrocytes and inhibited the MPP⁺-induced phosphorylation of MAPK and NF-κB. The anti-inflammatory effects of MHY2699 in protecting neurons were examined in an MPTP-induced mouse model of PD. MHY2699 inhibited MPTP-induced motor dysfunction and prevented dopaminergic neuronal death, suggesting that it attenuated neuroinflammation. Overall, MHY2699 has potential as a neuroprotective treatment for PD.Seulah LeeYeon Ji SuhYujeong LeeSeonguk YangDong Geun HongDinakaran ThirumalaiSeung-Cheol ChangKi Wung ChungYoung-Suk JungHyung Ryong MoonHae Young ChungJaewon LeeMDPI AGarticleParkinson’s diseaseneuroinflammationMHY2699barbiturateMPTPTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1855, p 1855 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Parkinson’s disease neuroinflammation MHY2699 barbiturate MPTP Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
Parkinson’s disease neuroinflammation MHY2699 barbiturate MPTP Therapeutics. Pharmacology RM1-950 Seulah Lee Yeon Ji Suh Yujeong Lee Seonguk Yang Dong Geun Hong Dinakaran Thirumalai Seung-Cheol Chang Ki Wung Chung Young-Suk Jung Hyung Ryong Moon Hae Young Chung Jaewon Lee Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease |
| description |
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined the neuroprotective effects of the barbiturate derivative, MHY2699 [5-(4-hydroxy 3,5-dimethoxybenzyl)-2 thioxodihydropyrimidine-4,6(1H,5H)-dione] in a mouse model of PD. MHY2699 ameliorated MPP⁺-induced astrocyte activation and ROS production in primary astrocytes and inhibited the MPP⁺-induced phosphorylation of MAPK and NF-κB. The anti-inflammatory effects of MHY2699 in protecting neurons were examined in an MPTP-induced mouse model of PD. MHY2699 inhibited MPTP-induced motor dysfunction and prevented dopaminergic neuronal death, suggesting that it attenuated neuroinflammation. Overall, MHY2699 has potential as a neuroprotective treatment for PD. |
| format |
article |
| author |
Seulah Lee Yeon Ji Suh Yujeong Lee Seonguk Yang Dong Geun Hong Dinakaran Thirumalai Seung-Cheol Chang Ki Wung Chung Young-Suk Jung Hyung Ryong Moon Hae Young Chung Jaewon Lee |
| author_facet |
Seulah Lee Yeon Ji Suh Yujeong Lee Seonguk Yang Dong Geun Hong Dinakaran Thirumalai Seung-Cheol Chang Ki Wung Chung Young-Suk Jung Hyung Ryong Moon Hae Young Chung Jaewon Lee |
| author_sort |
Seulah Lee |
| title |
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease |
| title_short |
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease |
| title_full |
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease |
| title_fullStr |
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease |
| title_full_unstemmed |
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease |
| title_sort |
anti-inflammatory effects of the novel barbiturate derivative mhy2699 in an mptp-induced mouse model of parkinson’s disease |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/24f95c4684064d02b96f11579314de8f |
| work_keys_str_mv |
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