Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation

McGee J Leonard,1 Catherine Bresee,2 Andrew Cruikshank1 1Animal Specialty and Emergency Center, Los Angeles, CA, USA; 2The Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: This is a retrospective multicenter study (2006–2012) e...

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Autores principales:	Leonard MJ, Bresee C, Cruikshank A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/24f9a33960484ea0b03db56aaeccf034
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spelling	oai:doaj.org-article:24f9a33960484ea0b03db56aaeccf0342021-12-02T06:26:39ZEffects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation2230-2034https://doaj.org/article/24f9a33960484ea0b03db56aaeccf0342014-10-01T00:00:00Zhttp://www.dovepress.com/effects-of-the-canine-rattlesnake-vaccine-in-moderate-to-severe-cases--peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034 McGee J Leonard,1 Catherine Bresee,2 Andrew Cruikshank1 1Animal Specialty and Emergency Center, Los Angeles, CA, USA; 2The Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: This is a retrospective multicenter study (2006–2012) examining a population of dogs with moderate to severe crotalid envenomation for protective effects of the canine rattlesnake vaccine. Five nonacademic emergency and referral veterinary hospitals in Southern California were involved in the study and contributed records regarding a total of 82 client-owned dogs that were treated for naturally occurring rattlesnake envenomation. All dogs received antivenin (Crotalidae) polyvalent, with dosages ranging from one to three vials (mean: 1.3±0.6). Fourteen dogs (17%) had a history of prior vaccination against crotalid venom. In univariate logistic regression modeling, cases with lower body weight (P=0.0001) or higher snakebite severity scores (P<0.0001) were associated with greater morbidity. No statistically significant difference in morbidity or mortality between vaccinated and unvaccinated dogs was found. The findings of this study did not identify a significantly protective effect of previous vaccination in the cases of moderate to severe rattlesnake envenomation that require treatment with antivenin. Keywords: rattlesnake envenomation, vaccine, antivenin, canineLeonard MJBresee CCruikshank ADove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2014, Iss default, Pp 153-158 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Leonard MJ Bresee C Cruikshank A Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
description	McGee J Leonard,1 Catherine Bresee,2 Andrew Cruikshank1 1Animal Specialty and Emergency Center, Los Angeles, CA, USA; 2The Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abstract: This is a retrospective multicenter study (2006–2012) examining a population of dogs with moderate to severe crotalid envenomation for protective effects of the canine rattlesnake vaccine. Five nonacademic emergency and referral veterinary hospitals in Southern California were involved in the study and contributed records regarding a total of 82 client-owned dogs that were treated for naturally occurring rattlesnake envenomation. All dogs received antivenin (Crotalidae) polyvalent, with dosages ranging from one to three vials (mean: 1.3±0.6). Fourteen dogs (17%) had a history of prior vaccination against crotalid venom. In univariate logistic regression modeling, cases with lower body weight (P=0.0001) or higher snakebite severity scores (P<0.0001) were associated with greater morbidity. No statistically significant difference in morbidity or mortality between vaccinated and unvaccinated dogs was found. The findings of this study did not identify a significantly protective effect of previous vaccination in the cases of moderate to severe rattlesnake envenomation that require treatment with antivenin. Keywords: rattlesnake envenomation, vaccine, antivenin, canine
format	article
author	Leonard MJ Bresee C Cruikshank A
author_facet	Leonard MJ Bresee C Cruikshank A
author_sort	Leonard MJ
title	Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
title_short	Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
title_full	Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
title_fullStr	Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
title_full_unstemmed	Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
title_sort	effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/24f9a33960484ea0b03db56aaeccf034
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Effects of the canine rattlesnake vaccine in moderate to severe cases of canine crotalid envenomation

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