Prolactin secretion in healthy adults is determined by gender, age and body mass index.

<h4>Background</h4>Prolactin (PRL) secretion is quantifiable as mean, peak and nadir PRL concentrations, degree of irregularity (ApEn, approximate entropy) and spikiness (brief staccato-like fluctuations).<h4>Hypothesis</h4>Distinct PRL dynamics reflect relatively distinct (c...

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Autores principales:	Ferdinand Roelfsema, Hanno Pijl, Daniel M Keenan, Johannes D Veldhuis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24f9a5a2861d4299a6d71d96e5d6efde
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spelling	oai:doaj.org-article:24f9a5a2861d4299a6d71d96e5d6efde2021-11-18T07:27:38ZProlactin secretion in healthy adults is determined by gender, age and body mass index.1932-620310.1371/journal.pone.0031305https://doaj.org/article/24f9a5a2861d4299a6d71d96e5d6efde2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363612/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Prolactin (PRL) secretion is quantifiable as mean, peak and nadir PRL concentrations, degree of irregularity (ApEn, approximate entropy) and spikiness (brief staccato-like fluctuations).<h4>Hypothesis</h4>Distinct PRL dynamics reflect relatively distinct (combinations of) subject variables, such as gender, age, and BMI.<h4>Location</h4>Clinical Research Unit.<h4>Subjects</h4>Seventy-four healthy adults aged 22-77 yr (41 women and 33 men), with BMI 18.3-39.4 kg/m(2).<h4>Measures</h4>Immunofluorometric PRL assay of 10-min samples collected for 24 hours.<h4>Results</h4>Mean 24-h PRL concentration correlated jointly with gender (P<0.0001) and BMI (P = 0.01), but not with age (overall R(2) = 0.308, P<0.0001). Nadir PRL concentration correlated with gender only (P = 0.017) and peak PRL with gender (P<0.001) and negatively with age (P<0.003), overall R(2) = 0.325, P<0.0001. Forward-selection multivariate regression of PRL deconvolution results demonstrated that basal (nonpulsatile) PRL secretion tended to be associated with BMI (R(2) = 0.058, P = 0.03), pulsatile secretion with gender (R(2) = 0.152, P = 0.003), and total secretion with gender and BMI (R(2) = 0.204, P<0.0001). Pulse mass was associated with gender (P = 0.001) and with a negative tendency to age (P = 0.038). In male subjects older than 50 yr (but not in women) approximate entropy was increased (0.942±0.301 vs. 1.258±0.267, P = 0.007) compared with younger men, as well as spikiness (0.363±0.122 vs. 0463±2.12, P = 0.031). Cosinor analysis disclosed higher mesor and amplitude in females than in men, but the acrophase was gender-independent. The acrophase was determined by age and BMI (R(2) = 0.186, P = 0.001).<h4>Conclusion</h4>In healthy adults, selective combinations of gender, age, and BMI specify distinct PRL dynamics, thus requiring balanced representation of these variables in comparative PRL studies.Ferdinand RoelfsemaHanno PijlDaniel M KeenanJohannes D VeldhuisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31305 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ferdinand Roelfsema Hanno Pijl Daniel M Keenan Johannes D Veldhuis Prolactin secretion in healthy adults is determined by gender, age and body mass index.
description	<h4>Background</h4>Prolactin (PRL) secretion is quantifiable as mean, peak and nadir PRL concentrations, degree of irregularity (ApEn, approximate entropy) and spikiness (brief staccato-like fluctuations).<h4>Hypothesis</h4>Distinct PRL dynamics reflect relatively distinct (combinations of) subject variables, such as gender, age, and BMI.<h4>Location</h4>Clinical Research Unit.<h4>Subjects</h4>Seventy-four healthy adults aged 22-77 yr (41 women and 33 men), with BMI 18.3-39.4 kg/m(2).<h4>Measures</h4>Immunofluorometric PRL assay of 10-min samples collected for 24 hours.<h4>Results</h4>Mean 24-h PRL concentration correlated jointly with gender (P<0.0001) and BMI (P = 0.01), but not with age (overall R(2) = 0.308, P<0.0001). Nadir PRL concentration correlated with gender only (P = 0.017) and peak PRL with gender (P<0.001) and negatively with age (P<0.003), overall R(2) = 0.325, P<0.0001. Forward-selection multivariate regression of PRL deconvolution results demonstrated that basal (nonpulsatile) PRL secretion tended to be associated with BMI (R(2) = 0.058, P = 0.03), pulsatile secretion with gender (R(2) = 0.152, P = 0.003), and total secretion with gender and BMI (R(2) = 0.204, P<0.0001). Pulse mass was associated with gender (P = 0.001) and with a negative tendency to age (P = 0.038). In male subjects older than 50 yr (but not in women) approximate entropy was increased (0.942±0.301 vs. 1.258±0.267, P = 0.007) compared with younger men, as well as spikiness (0.363±0.122 vs. 0463±2.12, P = 0.031). Cosinor analysis disclosed higher mesor and amplitude in females than in men, but the acrophase was gender-independent. The acrophase was determined by age and BMI (R(2) = 0.186, P = 0.001).<h4>Conclusion</h4>In healthy adults, selective combinations of gender, age, and BMI specify distinct PRL dynamics, thus requiring balanced representation of these variables in comparative PRL studies.
format	article
author	Ferdinand Roelfsema Hanno Pijl Daniel M Keenan Johannes D Veldhuis
author_facet	Ferdinand Roelfsema Hanno Pijl Daniel M Keenan Johannes D Veldhuis
author_sort	Ferdinand Roelfsema
title	Prolactin secretion in healthy adults is determined by gender, age and body mass index.
title_short	Prolactin secretion in healthy adults is determined by gender, age and body mass index.
title_full	Prolactin secretion in healthy adults is determined by gender, age and body mass index.
title_fullStr	Prolactin secretion in healthy adults is determined by gender, age and body mass index.
title_full_unstemmed	Prolactin secretion in healthy adults is determined by gender, age and body mass index.
title_sort	prolactin secretion in healthy adults is determined by gender, age and body mass index.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/24f9a5a2861d4299a6d71d96e5d6efde
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Prolactin secretion in healthy adults is determined by gender, age and body mass index.

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