Developmental Pathways Underlying Lung Development and Congenital Lung Disorders

Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to...

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Autores principales:	Inês Caldeira, Hugo Fernandes-Silva, Daniela Machado-Costa, Jorge Correia-Pinto, Rute Silva Moura
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	congenital pulmonary airway malformation (CPAM) bronchopulmonary sequestration bronchogenic cysts congenital diaphragmatic hernia (CDH) congenital malformations Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/24fd3238fd69472fa9966c6e00519efd
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spelling	oai:doaj.org-article:24fd3238fd69472fa9966c6e00519efd2021-11-25T17:10:06ZDevelopmental Pathways Underlying Lung Development and Congenital Lung Disorders10.3390/cells101129872073-4409https://doaj.org/article/24fd3238fd69472fa9966c6e00519efd2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2987https://doaj.org/toc/2073-4409Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal survival or affect/disrupt lung function through early life and adulthood. Conditions like congenital pulmonary airway malformation, bronchopulmonary sequestration, bronchogenic cysts, and congenital diaphragmatic hernia display unique forms of lung abnormalities. The etiology of these disorders is not yet completely understood; however, specific developmental pathways have already been reported as deregulated. In this sense, this review focuses on the molecular mechanisms that contribute to normal/abnormal lung growth and development and their impact on postnatal survival.Inês CaldeiraHugo Fernandes-SilvaDaniela Machado-CostaJorge Correia-PintoRute Silva MouraMDPI AGarticlecongenital pulmonary airway malformation (CPAM)bronchopulmonary sequestrationbronchogenic cystscongenital diaphragmatic hernia (CDH)congenital malformationsBiology (General)QH301-705.5ENCells, Vol 10, Iss 2987, p 2987 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	congenital pulmonary airway malformation (CPAM) bronchopulmonary sequestration bronchogenic cysts congenital diaphragmatic hernia (CDH) congenital malformations Biology (General) QH301-705.5
spellingShingle	congenital pulmonary airway malformation (CPAM) bronchopulmonary sequestration bronchogenic cysts congenital diaphragmatic hernia (CDH) congenital malformations Biology (General) QH301-705.5 Inês Caldeira Hugo Fernandes-Silva Daniela Machado-Costa Jorge Correia-Pinto Rute Silva Moura Developmental Pathways Underlying Lung Development and Congenital Lung Disorders
description	Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal survival or affect/disrupt lung function through early life and adulthood. Conditions like congenital pulmonary airway malformation, bronchopulmonary sequestration, bronchogenic cysts, and congenital diaphragmatic hernia display unique forms of lung abnormalities. The etiology of these disorders is not yet completely understood; however, specific developmental pathways have already been reported as deregulated. In this sense, this review focuses on the molecular mechanisms that contribute to normal/abnormal lung growth and development and their impact on postnatal survival.
format	article
author	Inês Caldeira Hugo Fernandes-Silva Daniela Machado-Costa Jorge Correia-Pinto Rute Silva Moura
author_facet	Inês Caldeira Hugo Fernandes-Silva Daniela Machado-Costa Jorge Correia-Pinto Rute Silva Moura
author_sort	Inês Caldeira
title	Developmental Pathways Underlying Lung Development and Congenital Lung Disorders
title_short	Developmental Pathways Underlying Lung Development and Congenital Lung Disorders
title_full	Developmental Pathways Underlying Lung Development and Congenital Lung Disorders
title_fullStr	Developmental Pathways Underlying Lung Development and Congenital Lung Disorders
title_full_unstemmed	Developmental Pathways Underlying Lung Development and Congenital Lung Disorders
title_sort	developmental pathways underlying lung development and congenital lung disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/24fd3238fd69472fa9966c6e00519efd
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Developmental Pathways Underlying Lung Development and Congenital Lung Disorders

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