Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia

Background. Pneumonia is a common disease among the aging population in Japan. Hence, it is important to elucidate the risks related to pneumonia mortality. Since Streptococcus pneumoniae is the most commonly observed pathogen, pneumococcal vaccination is recommended to older adults. Therefore, this...

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Autores principales:	Nobuhiko Fukuda, Nobuaki Kobayashi, Makoto Masuda, Aya Wakabayashi, Nobuko Kusano, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Masanori Nishikawa, Takeshi Kaneko
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/24fdd6b6b0324ad3be11aad417af5810
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spelling	oai:doaj.org-article:24fdd6b6b0324ad3be11aad417af58102021-11-29T00:55:36ZClinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia1916-724510.1155/2021/5644824https://doaj.org/article/24fdd6b6b0324ad3be11aad417af58102021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5644824https://doaj.org/toc/1916-7245Background. Pneumonia is a common disease among the aging population in Japan. Hence, it is important to elucidate the risks related to pneumonia mortality. Since Streptococcus pneumoniae is the most commonly observed pathogen, pneumococcal vaccination is recommended to older adults. Therefore, this study aimed to clarify the clinical features of pneumonia, including the status of pneumococcal vaccination, in hospitalized older adult patients in Japan. Methods. This single-centered retrospective study was conducted by reviewing the medical records of all patients with acute pneumonia at Fujisawa City Hospital in Japan from April 2018 to March 2019. Patients were divided into two groups based on their history of pneumococcal vaccination. The primary endpoint was in-hospital mortality, while the secondary endpoint was risk factors associated with mortality. Results. We included 93 patients with pneumonia in this retrospective study. Although the mortality rate was higher in the vaccinated group (15.8%) than in the unvaccinated group (9.1%), vaccination status was not identified as a significant risk factor for mortality after multivariable logistic regression (odds ratio: 2.71; 95% confidence interval: 0.667–11.02; p=0.16). In addition, the A-DROP score was identified as an independent risk factor (odds ratio: 2.64; 95% confidence interval: 1.22–5.72; p=0.008). Conclusions. Our study suggested that the A-DROP score is a risk factor of mortality for pneumonia in older adults. In addition, pneumococcal vaccination history was related to increased mortality; however, the influence of the vaccination remains unclear because of the small sample size.Nobuhiko FukudaNobuaki KobayashiMakoto MasudaAya WakabayashiNobuko KusanoKeisuke WatanabeNobuyuki HoritaYu HaraMasanori NishikawaTakeshi KanekoHindawi LimitedarticleDiseases of the respiratory systemRC705-779ENCanadian Respiratory Journal, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Nobuhiko Fukuda Nobuaki Kobayashi Makoto Masuda Aya Wakabayashi Nobuko Kusano Keisuke Watanabe Nobuyuki Horita Yu Hara Masanori Nishikawa Takeshi Kaneko Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia
description	Background. Pneumonia is a common disease among the aging population in Japan. Hence, it is important to elucidate the risks related to pneumonia mortality. Since Streptococcus pneumoniae is the most commonly observed pathogen, pneumococcal vaccination is recommended to older adults. Therefore, this study aimed to clarify the clinical features of pneumonia, including the status of pneumococcal vaccination, in hospitalized older adult patients in Japan. Methods. This single-centered retrospective study was conducted by reviewing the medical records of all patients with acute pneumonia at Fujisawa City Hospital in Japan from April 2018 to March 2019. Patients were divided into two groups based on their history of pneumococcal vaccination. The primary endpoint was in-hospital mortality, while the secondary endpoint was risk factors associated with mortality. Results. We included 93 patients with pneumonia in this retrospective study. Although the mortality rate was higher in the vaccinated group (15.8%) than in the unvaccinated group (9.1%), vaccination status was not identified as a significant risk factor for mortality after multivariable logistic regression (odds ratio: 2.71; 95% confidence interval: 0.667–11.02; p=0.16). In addition, the A-DROP score was identified as an independent risk factor (odds ratio: 2.64; 95% confidence interval: 1.22–5.72; p=0.008). Conclusions. Our study suggested that the A-DROP score is a risk factor of mortality for pneumonia in older adults. In addition, pneumococcal vaccination history was related to increased mortality; however, the influence of the vaccination remains unclear because of the small sample size.
format	article
author	Nobuhiko Fukuda Nobuaki Kobayashi Makoto Masuda Aya Wakabayashi Nobuko Kusano Keisuke Watanabe Nobuyuki Horita Yu Hara Masanori Nishikawa Takeshi Kaneko
author_facet	Nobuhiko Fukuda Nobuaki Kobayashi Makoto Masuda Aya Wakabayashi Nobuko Kusano Keisuke Watanabe Nobuyuki Horita Yu Hara Masanori Nishikawa Takeshi Kaneko
author_sort	Nobuhiko Fukuda
title	Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia
title_short	Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia
title_full	Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia
title_fullStr	Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia
title_full_unstemmed	Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia
title_sort	clinical features and risk factors for mortality in hospitalized older adults with pneumonia
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/24fdd6b6b0324ad3be11aad417af5810
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_version_	1718407757869088768

Clinical Features and Risk Factors for Mortality in Hospitalized Older Adults with Pneumonia

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