Step by Step: Managing the Complications of Cirrhosis

Irene Perez,1 Fabian J Bolte,1 William Bigelow,1 Zachary Dickson,2 Neeral L Shah2 1Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA; 2Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USACorrespondence: Neeral L ShahDivision of...

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Autores principales:	Perez IC, Bolte FJ, Bigelow W, Dickson Z, Shah NL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cirrhosis chronic liver disease end-stage liver disease decompensated cirrhosis compensated cirrhosis hepatorenal syndrome Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/24ff2bb3909e41e5b650358823d7b82a
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spelling	oai:doaj.org-article:24ff2bb3909e41e5b650358823d7b82a2021-12-02T14:57:35ZStep by Step: Managing the Complications of Cirrhosis1179-1535https://doaj.org/article/24ff2bb3909e41e5b650358823d7b82a2021-05-01T00:00:00Zhttps://www.dovepress.com/step-by-step-managing-the-complications-of-cirrhosis-peer-reviewed-fulltext-article-HMERhttps://doaj.org/toc/1179-1535Irene Perez,1 Fabian J Bolte,1 William Bigelow,1 Zachary Dickson,2 Neeral L Shah2 1Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA; 2Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USACorrespondence: Neeral L ShahDivision of Gastroenterology and Hepatology, University of Virginia, PO. Box 800708, West Complex – 2nd Floor, Charlottesville, VA, 22908, USA, Tel +1 434-297-7206Fax +1 434-244-7586Email neeral.shah@virginia.eduAbstract: According to the Centers for Disease Control and Prevention, chronic liver disease and cirrhosis is the 11th leading cause of death in the United States. Common causes of chronic liver disease include alcohol, viral hepatitis, and non-alcoholic steatohepatitis (NASH). Inflammation is a critical driver in the progression of liver disease to liver fibrosis and ultimately cirrhosis. While the severity of chronic liver disease extends over a continuum, the management is more easily differentiated between compensated and decompensated cirrhosis. In this review, we discuss pathophysiology, clinical features and management of common complications of liver cirrhosis based on literature review and the current clinical practice guidelines of the American Association for the Study of Liver Diseases (AASLD).Keywords: cirrhosis, chronic liver disease, end-stage liver disease, decompensated cirrhosis, compensated cirrhosis, hepatorenal syndromePerez ICBolte FJBigelow WDickson ZShah NLDove Medical Pressarticlecirrhosischronic liver diseaseend-stage liver diseasedecompensated cirrhosiscompensated cirrhosishepatorenal syndromeDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 13, Pp 45-57 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cirrhosis chronic liver disease end-stage liver disease decompensated cirrhosis compensated cirrhosis hepatorenal syndrome Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	cirrhosis chronic liver disease end-stage liver disease decompensated cirrhosis compensated cirrhosis hepatorenal syndrome Diseases of the digestive system. Gastroenterology RC799-869 Perez IC Bolte FJ Bigelow W Dickson Z Shah NL Step by Step: Managing the Complications of Cirrhosis
description	Irene Perez,1 Fabian J Bolte,1 William Bigelow,1 Zachary Dickson,2 Neeral L Shah2 1Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA; 2Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USACorrespondence: Neeral L ShahDivision of Gastroenterology and Hepatology, University of Virginia, PO. Box 800708, West Complex – 2nd Floor, Charlottesville, VA, 22908, USA, Tel +1 434-297-7206Fax +1 434-244-7586Email neeral.shah@virginia.eduAbstract: According to the Centers for Disease Control and Prevention, chronic liver disease and cirrhosis is the 11th leading cause of death in the United States. Common causes of chronic liver disease include alcohol, viral hepatitis, and non-alcoholic steatohepatitis (NASH). Inflammation is a critical driver in the progression of liver disease to liver fibrosis and ultimately cirrhosis. While the severity of chronic liver disease extends over a continuum, the management is more easily differentiated between compensated and decompensated cirrhosis. In this review, we discuss pathophysiology, clinical features and management of common complications of liver cirrhosis based on literature review and the current clinical practice guidelines of the American Association for the Study of Liver Diseases (AASLD).Keywords: cirrhosis, chronic liver disease, end-stage liver disease, decompensated cirrhosis, compensated cirrhosis, hepatorenal syndrome
format	article
author	Perez IC Bolte FJ Bigelow W Dickson Z Shah NL
author_facet	Perez IC Bolte FJ Bigelow W Dickson Z Shah NL
author_sort	Perez IC
title	Step by Step: Managing the Complications of Cirrhosis
title_short	Step by Step: Managing the Complications of Cirrhosis
title_full	Step by Step: Managing the Complications of Cirrhosis
title_fullStr	Step by Step: Managing the Complications of Cirrhosis
title_full_unstemmed	Step by Step: Managing the Complications of Cirrhosis
title_sort	step by step: managing the complications of cirrhosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/24ff2bb3909e41e5b650358823d7b82a
work_keys_str_mv	AT perezic stepbystepmanagingthecomplicationsofcirrhosis AT boltefj stepbystepmanagingthecomplicationsofcirrhosis AT bigeloww stepbystepmanagingthecomplicationsofcirrhosis AT dicksonz stepbystepmanagingthecomplicationsofcirrhosis AT shahnl stepbystepmanagingthecomplicationsofcirrhosis
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Step by Step: Managing the Complications of Cirrhosis

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