Ocular hypertension and hypotony as determinates of outcomes in uveitis

Rabia Aman,1 Stephanie B Engelhard,1 Asima Bajwa,1 James Patrie,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To assess ocular hypertension (OHT) and hypotony as outcomes of uveitis in patients mana...

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Autores principales:	Aman R, Engelhard SB, Bajwa A, Patrie J, Reddy AK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Uveitis ocular hypertension (OHT) hypotony intraocular pressure (IOP) uveitic glaucoma Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2503325470b94d6a8ac65af3e445f182
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spelling	oai:doaj.org-article:2503325470b94d6a8ac65af3e445f1822021-12-02T00:20:10ZOcular hypertension and hypotony as determinates of outcomes in uveitis1177-5483https://doaj.org/article/2503325470b94d6a8ac65af3e445f1822015-12-01T00:00:00Zhttps://www.dovepress.com/ocular-hypertension-and-hypotony-as-determinates-of-outcomes-in-uveiti-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Rabia Aman,1 Stephanie B Engelhard,1 Asima Bajwa,1 James Patrie,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To assess ocular hypertension (OHT) and hypotony as outcomes of uveitis in patients managed in a mid-Atlantic tertiary care center. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Results: A total of 442 patients (582 eyes) with uveitis were identified and included in the study. The patient population was 57.0% female. Overall, 61.9% were Caucasian and 26.6% were African American. Mean age was 46.8 years. Overall, 11.5% of the eyes had OHT at initial visit, and 7.9% had OHT at final visit (P=0.035). For each additional decade of life, the odds that an eye had OHT were elevated by a factor of 1.15 (95% confidence interval [CI]: [1.02, 1.30], P=0.027) at initial visit and by a factor of 1.15 (95% CI: [1.00, 1.32], P=0.055) at final visit. The odds that an anterior uveitis eye had OHT were greater by a factor of 2.50 (95% CI: [1.22, 5.14], P=0.013) than the odds for a nonanterior uveitis eye at initial visit and greater by a factor of 2.61 (95% CI: [1.24, 5.50], P=0.011) at final visit. For each additional 0.5 logarithm of the minimum angle of resolution increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P=0.047) at initial visit and 1.23 (95% CI: [0.99, 1.54], P=0.065) at final visit. Overall, 21 of 582 eyes (3.6%) were hypotonous initially, while 24 of 582 eyes (4.1%) were hypotonous at final follow-up (P=0.631). Conclusion: OHT was associated with increasing age, anterior uveitis, and poor presenting visual acuity. Ocular hypotony was more common in anterior uveitis than in nonanterior uveitis. Fluctuations in intraocular pressure are an important cause of visual impairment in patients with uveitis. Careful monitoring of all uveitis patients, and especially those most at risk for fluctuations in intraocular pressure, can preserve vision and improve patient outcomes. Keywords: uveitis, ocular hypertension, hypotony, intraocular pressure, uveitic glaucomaAman REngelhard SBBajwa APatrie JReddy AKDove Medical PressarticleUveitisocular hypertension (OHT)hypotonyintraocular pressure (IOP)uveitic glaucomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss Issue 1, Pp 2291-2298 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Uveitis ocular hypertension (OHT) hypotony intraocular pressure (IOP) uveitic glaucoma Ophthalmology RE1-994
spellingShingle	Uveitis ocular hypertension (OHT) hypotony intraocular pressure (IOP) uveitic glaucoma Ophthalmology RE1-994 Aman R Engelhard SB Bajwa A Patrie J Reddy AK Ocular hypertension and hypotony as determinates of outcomes in uveitis
description	Rabia Aman,1 Stephanie B Engelhard,1 Asima Bajwa,1 James Patrie,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To assess ocular hypertension (OHT) and hypotony as outcomes of uveitis in patients managed in a mid-Atlantic tertiary care center. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Results: A total of 442 patients (582 eyes) with uveitis were identified and included in the study. The patient population was 57.0% female. Overall, 61.9% were Caucasian and 26.6% were African American. Mean age was 46.8 years. Overall, 11.5% of the eyes had OHT at initial visit, and 7.9% had OHT at final visit (P=0.035). For each additional decade of life, the odds that an eye had OHT were elevated by a factor of 1.15 (95% confidence interval [CI]: [1.02, 1.30], P=0.027) at initial visit and by a factor of 1.15 (95% CI: [1.00, 1.32], P=0.055) at final visit. The odds that an anterior uveitis eye had OHT were greater by a factor of 2.50 (95% CI: [1.22, 5.14], P=0.013) than the odds for a nonanterior uveitis eye at initial visit and greater by a factor of 2.61 (95% CI: [1.24, 5.50], P=0.011) at final visit. For each additional 0.5 logarithm of the minimum angle of resolution increase in initial visual acuity, the odds that an affected eye had OHT were elevated by a factor of 1.18 (95% CI: [1.00, 1.39], P=0.047) at initial visit and 1.23 (95% CI: [0.99, 1.54], P=0.065) at final visit. Overall, 21 of 582 eyes (3.6%) were hypotonous initially, while 24 of 582 eyes (4.1%) were hypotonous at final follow-up (P=0.631). Conclusion: OHT was associated with increasing age, anterior uveitis, and poor presenting visual acuity. Ocular hypotony was more common in anterior uveitis than in nonanterior uveitis. Fluctuations in intraocular pressure are an important cause of visual impairment in patients with uveitis. Careful monitoring of all uveitis patients, and especially those most at risk for fluctuations in intraocular pressure, can preserve vision and improve patient outcomes. Keywords: uveitis, ocular hypertension, hypotony, intraocular pressure, uveitic glaucoma
format	article
author	Aman R Engelhard SB Bajwa A Patrie J Reddy AK
author_facet	Aman R Engelhard SB Bajwa A Patrie J Reddy AK
author_sort	Aman R
title	Ocular hypertension and hypotony as determinates of outcomes in uveitis
title_short	Ocular hypertension and hypotony as determinates of outcomes in uveitis
title_full	Ocular hypertension and hypotony as determinates of outcomes in uveitis
title_fullStr	Ocular hypertension and hypotony as determinates of outcomes in uveitis
title_full_unstemmed	Ocular hypertension and hypotony as determinates of outcomes in uveitis
title_sort	ocular hypertension and hypotony as determinates of outcomes in uveitis
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/2503325470b94d6a8ac65af3e445f182
work_keys_str_mv	AT amanr ocularhypertensionandhypotonyasdeterminatesofoutcomesinuveitis AT engelhardsb ocularhypertensionandhypotonyasdeterminatesofoutcomesinuveitis AT bajwaa ocularhypertensionandhypotonyasdeterminatesofoutcomesinuveitis AT patriej ocularhypertensionandhypotonyasdeterminatesofoutcomesinuveitis AT reddyak ocularhypertensionandhypotonyasdeterminatesofoutcomesinuveitis
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Ocular hypertension and hypotony as determinates of outcomes in uveitis

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