Brain Tumor Heterogeneity

Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic...

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Detalles Bibliográficos
Autores principales: Telmo Augusto Barba Belsuzarri, Maick Willen Fernandes Neves, Otávio Augusto da Costa, Diego Alves Soares, Fernando Antônio de Melo Filho, Mariana Mazzuia Guimarães, Tiago Fernandes Gonçales, Wolnei Marques Zeviani, João Flávio Mattos Araújo
Formato: article
Lenguaje:EN
Publicado: Thieme Revinter Publicações Ltda. 2018
Materias:
R
Acceso en línea:https://doaj.org/article/2507634095fa4af69ede651b774f7c1e
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Sumario:Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic inflammation, microenvironment, epigenetics and glioma steam cells. Brain tumors remain a challenge with regards to medication and disease, due to the lack of treatment options and unsatisfactory results. These results might be the result of the brain tumor heterogeneity and its multiple resistance mechanisms to chemo and radiotherapy.