Alteration of corneal biomechanical properties in patients with dry eye disease.

<h4>Purpose</h4>To evaluate the association between symptoms and signs of dry eye diseases (DED) with corneal biomechanical parameters.<h4>Methods</h4>This cross-sectional study enrolled 81 participants without history of ocular hypertension, glaucoma, keratoconus, corneal ed...

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Autores principales:	Vannarut Satitpitakul, Parichart Taweekitikul, Vilavun Puangsricharern, Ngamjit Kasetsuwan, Usanee Reinprayoon, Thanachaporn Kittipibul
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/250ac411fd594615bbf4bf953711f1ae
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spelling	oai:doaj.org-article:250ac411fd594615bbf4bf953711f1ae2021-12-02T20:15:28ZAlteration of corneal biomechanical properties in patients with dry eye disease.1932-620310.1371/journal.pone.0254442https://doaj.org/article/250ac411fd594615bbf4bf953711f1ae2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254442https://doaj.org/toc/1932-6203<h4>Purpose</h4>To evaluate the association between symptoms and signs of dry eye diseases (DED) with corneal biomechanical parameters.<h4>Methods</h4>This cross-sectional study enrolled 81 participants without history of ocular hypertension, glaucoma, keratoconus, corneal edema, contact lens use, diabetes, and ocular surgery. All participants were evaluated for symptoms and signs of DED using OSDI questionnaire, tear film break-up time (TBUT), conjunctival and corneal staining (NEI grading) and Schirmer test. Corneal biomechanical parameters were obtained using Corvis ST. Mixed-effects linear regression analysis was used to determine the association between symptoms and signs of DED with corneal biomechanical parameters. Difference in corneal biomechanical parameter between participants with low (Schirmer value ≤10 mm; LT group) and normal (Schirmer value >10mm; NT group) tear production was analyzed using ANCOVA test.<h4>Results</h4>The median OSDI scores, TBUT, conjunctival and corneal staining scores as well as Schirmer test were 13±16.5 (range; 0-77), 5.3±4.2 seconds (range; 1.3-11), 0±1 (range; 0-4), 0±2 (ranges; 0-9) and 16±14 mm (range; 0-45) respectively. Regression analysis adjusted with participants' refraction, intraocular pressure, and central corneal thickness showed that OSDI had a negative association with highest concavity radius (P = 0.02). The association between DED signs and corneal biomechanical parameters were found between conjunctival staining scores with second applanation velocity (A2V, P = 0.04), corneal staining scores with second applanation length (A2L, P = 0.01), Schirmer test with first applanation time (A1T, P = 0.04) and first applanation velocity (P = 0.01). In subgroup analysis, there was no difference in corneal biomechanical parameters between participants with low and normal tear production (P>0.05). The associations were found between OSDI with time to highest concavity (P<0.01) and highest displacement of corneal apex (HC-DA, P = 0.04), conjunctival staining scores with A2L (P = 0.01) and A2V (P<0.01) in LT group, and Schirmer test with A1T (P = 0.02) and HC-DA (P = 0.03), corneal staining scores with A2L (P<0.01) in NT group.<h4>Conclusions</h4>According to in vivo observation with Corvis ST, patients with DED showed more compliant corneas. The increase in dry eye severity was associated with the worsening of corneal biomechanics in both patients with low and normal tear production.Vannarut SatitpitakulParichart TaweekitikulVilavun PuangsricharernNgamjit KasetsuwanUsanee ReinprayoonThanachaporn KittipibulPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254442 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vannarut Satitpitakul Parichart Taweekitikul Vilavun Puangsricharern Ngamjit Kasetsuwan Usanee Reinprayoon Thanachaporn Kittipibul Alteration of corneal biomechanical properties in patients with dry eye disease.
description	<h4>Purpose</h4>To evaluate the association between symptoms and signs of dry eye diseases (DED) with corneal biomechanical parameters.<h4>Methods</h4>This cross-sectional study enrolled 81 participants without history of ocular hypertension, glaucoma, keratoconus, corneal edema, contact lens use, diabetes, and ocular surgery. All participants were evaluated for symptoms and signs of DED using OSDI questionnaire, tear film break-up time (TBUT), conjunctival and corneal staining (NEI grading) and Schirmer test. Corneal biomechanical parameters were obtained using Corvis ST. Mixed-effects linear regression analysis was used to determine the association between symptoms and signs of DED with corneal biomechanical parameters. Difference in corneal biomechanical parameter between participants with low (Schirmer value ≤10 mm; LT group) and normal (Schirmer value >10mm; NT group) tear production was analyzed using ANCOVA test.<h4>Results</h4>The median OSDI scores, TBUT, conjunctival and corneal staining scores as well as Schirmer test were 13±16.5 (range; 0-77), 5.3±4.2 seconds (range; 1.3-11), 0±1 (range; 0-4), 0±2 (ranges; 0-9) and 16±14 mm (range; 0-45) respectively. Regression analysis adjusted with participants' refraction, intraocular pressure, and central corneal thickness showed that OSDI had a negative association with highest concavity radius (P = 0.02). The association between DED signs and corneal biomechanical parameters were found between conjunctival staining scores with second applanation velocity (A2V, P = 0.04), corneal staining scores with second applanation length (A2L, P = 0.01), Schirmer test with first applanation time (A1T, P = 0.04) and first applanation velocity (P = 0.01). In subgroup analysis, there was no difference in corneal biomechanical parameters between participants with low and normal tear production (P>0.05). The associations were found between OSDI with time to highest concavity (P<0.01) and highest displacement of corneal apex (HC-DA, P = 0.04), conjunctival staining scores with A2L (P = 0.01) and A2V (P<0.01) in LT group, and Schirmer test with A1T (P = 0.02) and HC-DA (P = 0.03), corneal staining scores with A2L (P<0.01) in NT group.<h4>Conclusions</h4>According to in vivo observation with Corvis ST, patients with DED showed more compliant corneas. The increase in dry eye severity was associated with the worsening of corneal biomechanics in both patients with low and normal tear production.
format	article
author	Vannarut Satitpitakul Parichart Taweekitikul Vilavun Puangsricharern Ngamjit Kasetsuwan Usanee Reinprayoon Thanachaporn Kittipibul
author_facet	Vannarut Satitpitakul Parichart Taweekitikul Vilavun Puangsricharern Ngamjit Kasetsuwan Usanee Reinprayoon Thanachaporn Kittipibul
author_sort	Vannarut Satitpitakul
title	Alteration of corneal biomechanical properties in patients with dry eye disease.
title_short	Alteration of corneal biomechanical properties in patients with dry eye disease.
title_full	Alteration of corneal biomechanical properties in patients with dry eye disease.
title_fullStr	Alteration of corneal biomechanical properties in patients with dry eye disease.
title_full_unstemmed	Alteration of corneal biomechanical properties in patients with dry eye disease.
title_sort	alteration of corneal biomechanical properties in patients with dry eye disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/250ac411fd594615bbf4bf953711f1ae
work_keys_str_mv	AT vannarutsatitpitakul alterationofcornealbiomechanicalpropertiesinpatientswithdryeyedisease AT paricharttaweekitikul alterationofcornealbiomechanicalpropertiesinpatientswithdryeyedisease AT vilavunpuangsricharern alterationofcornealbiomechanicalpropertiesinpatientswithdryeyedisease AT ngamjitkasetsuwan alterationofcornealbiomechanicalpropertiesinpatientswithdryeyedisease AT usaneereinprayoon alterationofcornealbiomechanicalpropertiesinpatientswithdryeyedisease AT thanachapornkittipibul alterationofcornealbiomechanicalpropertiesinpatientswithdryeyedisease
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Alteration of corneal biomechanical properties in patients with dry eye disease.

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