KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.

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Autores principales:	Marjorie Fournier, Meritxell Orpinell, Cédric Grauffel, Elisabeth Scheer, Jean-Marie Garnier, Tao Ye, Virginie Chavant, Mathilde Joint, Fumiko Esashi, Annick Dejaegere, Pierre Gönczy, László Tora
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/250c67199f71459cb19a3733c6507eda
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spelling	oai:doaj.org-article:250c67199f71459cb19a3733c6507eda2021-12-02T14:39:49ZKAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification10.1038/ncomms132272041-1723https://doaj.org/article/250c67199f71459cb19a3733c6507eda2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13227https://doaj.org/toc/2041-1723The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.Marjorie FournierMeritxell OrpinellCédric GrauffelElisabeth ScheerJean-Marie GarnierTao YeVirginie ChavantMathilde JointFumiko EsashiAnnick DejaegerePierre GönczyLászló ToraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marjorie Fournier Meritxell Orpinell Cédric Grauffel Elisabeth Scheer Jean-Marie Garnier Tao Ye Virginie Chavant Mathilde Joint Fumiko Esashi Annick Dejaegere Pierre Gönczy László Tora KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
description	The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the regulation of centrosome number.
format	article
author	Marjorie Fournier Meritxell Orpinell Cédric Grauffel Elisabeth Scheer Jean-Marie Garnier Tao Ye Virginie Chavant Mathilde Joint Fumiko Esashi Annick Dejaegere Pierre Gönczy László Tora
author_facet	Marjorie Fournier Meritxell Orpinell Cédric Grauffel Elisabeth Scheer Jean-Marie Garnier Tao Ye Virginie Chavant Mathilde Joint Fumiko Esashi Annick Dejaegere Pierre Gönczy László Tora
author_sort	Marjorie Fournier
title	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_short	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_full	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_fullStr	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_full_unstemmed	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification
title_sort	kat2a/kat2b-targeted acetylome reveals a role for plk4 acetylation in preventing centrosome amplification
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/250c67199f71459cb19a3733c6507eda
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KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

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