Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience

Neil S Kalbag, Nenita Maganti, Alice T Lyon, Rukhsana G Mirza Department of Ophthalmology, Northwestern University, Chicago, IL, USACorrespondence: Rukhsana G MirzaDepartment of Ophthalmology, Northwestern University, Chicago, IL, USAEmail r-mirza@northwestern.eduAim: To investigate the prevalence o...

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Autores principales:	Kalbag NS, Maganti N, Lyon AT, Mirza RG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	interstitial cystitis ic maculopathy pentosan polysulfate sodium pps Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/250d32a05f6f48ee8a264b782b53ff1f
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spelling	oai:doaj.org-article:250d32a05f6f48ee8a264b782b53ff1f2021-12-02T14:24:10ZMaculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience1177-5483https://doaj.org/article/250d32a05f6f48ee8a264b782b53ff1f2021-02-01T00:00:00Zhttps://www.dovepress.com/maculopathy-secondary-to-pentosan-polysulfate-use-a-single-center-expe-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Neil S Kalbag, Nenita Maganti, Alice T Lyon, Rukhsana G Mirza Department of Ophthalmology, Northwestern University, Chicago, IL, USACorrespondence: Rukhsana G MirzaDepartment of Ophthalmology, Northwestern University, Chicago, IL, USAEmail r-mirza@northwestern.eduAim: To investigate the prevalence of retinal pathology in patients with a history of exposure to pentosan polysulfate sodium (PPS).Methods: Patients exposed to PPS and seen in the ophthalmology clinic at Northwestern University during 1/1/2002 to 1/1/2019 were identified from electronic health records (EHR) by an electronic data warehouse (EDW) search. Visual acuity (VA), reasons for clinic visit, ocular conditions, and duration of exposure to PPS were noted. Chart review was performed for fundus exam findings and ophthalmologic imaging, specifically fundus photography, fundus autofluorescence, and ocular coherence tomography (OCT) images. When OCT or fundus photography was available, studies were evaluated by two independent graders.Results: A total of 131 patients who were exposed to PPS and seen at the Northwestern Ophthalmology clinic were identified in the EHR. Forty patients of 131 had imaging. Patients with imaging or fundus examination suspicious for PPS maculopathy were placed into the suspect group. Of the 40 patients that had imaging, 5 (12.5%) had features suspicious for PPS maculopathy. Of the remaining 91, 5 (5.4%) had macular pigmentary changes described on fundus exam. Among the 10 patients in the suspect group, the average duration of PPS use was 4.2 years (range 0.3– 11.6 years, interquartile range 5.5 years) and the average cumulative dose was 380g (range 29– 1092g, interquartile range 132g).Conclusion: A novel drug-induced maculopathy has been associated with PPS use with a distinct clinical constellation that can be accurately identified with multimodal imaging.Keywords: interstitial cystitis, IC, maculopathy, pentosan polysulfate sodium, PPSKalbag NSMaganti NLyon ATMirza RGDove Medical Pressarticleinterstitial cystitisicmaculopathypentosan polysulfate sodiumppsOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 513-519 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interstitial cystitis ic maculopathy pentosan polysulfate sodium pps Ophthalmology RE1-994
spellingShingle	interstitial cystitis ic maculopathy pentosan polysulfate sodium pps Ophthalmology RE1-994 Kalbag NS Maganti N Lyon AT Mirza RG Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience
description	Neil S Kalbag, Nenita Maganti, Alice T Lyon, Rukhsana G Mirza Department of Ophthalmology, Northwestern University, Chicago, IL, USACorrespondence: Rukhsana G MirzaDepartment of Ophthalmology, Northwestern University, Chicago, IL, USAEmail r-mirza@northwestern.eduAim: To investigate the prevalence of retinal pathology in patients with a history of exposure to pentosan polysulfate sodium (PPS).Methods: Patients exposed to PPS and seen in the ophthalmology clinic at Northwestern University during 1/1/2002 to 1/1/2019 were identified from electronic health records (EHR) by an electronic data warehouse (EDW) search. Visual acuity (VA), reasons for clinic visit, ocular conditions, and duration of exposure to PPS were noted. Chart review was performed for fundus exam findings and ophthalmologic imaging, specifically fundus photography, fundus autofluorescence, and ocular coherence tomography (OCT) images. When OCT or fundus photography was available, studies were evaluated by two independent graders.Results: A total of 131 patients who were exposed to PPS and seen at the Northwestern Ophthalmology clinic were identified in the EHR. Forty patients of 131 had imaging. Patients with imaging or fundus examination suspicious for PPS maculopathy were placed into the suspect group. Of the 40 patients that had imaging, 5 (12.5%) had features suspicious for PPS maculopathy. Of the remaining 91, 5 (5.4%) had macular pigmentary changes described on fundus exam. Among the 10 patients in the suspect group, the average duration of PPS use was 4.2 years (range 0.3– 11.6 years, interquartile range 5.5 years) and the average cumulative dose was 380g (range 29– 1092g, interquartile range 132g).Conclusion: A novel drug-induced maculopathy has been associated with PPS use with a distinct clinical constellation that can be accurately identified with multimodal imaging.Keywords: interstitial cystitis, IC, maculopathy, pentosan polysulfate sodium, PPS
format	article
author	Kalbag NS Maganti N Lyon AT Mirza RG
author_facet	Kalbag NS Maganti N Lyon AT Mirza RG
author_sort	Kalbag NS
title	Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience
title_short	Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience
title_full	Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience
title_fullStr	Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience
title_full_unstemmed	Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience
title_sort	maculopathy secondary to pentosan polysulfate use: a single-center experience
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/250d32a05f6f48ee8a264b782b53ff1f
work_keys_str_mv	AT kalbagns maculopathysecondarytopentosanpolysulfateuseasinglecenterexperience AT magantin maculopathysecondarytopentosanpolysulfateuseasinglecenterexperience AT lyonat maculopathysecondarytopentosanpolysulfateuseasinglecenterexperience AT mirzarg maculopathysecondarytopentosanpolysulfateuseasinglecenterexperience
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Maculopathy Secondary to Pentosan Polysulfate Use: A Single-Center Experience

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