Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study

Xiaoli Gong,1 Yufeng Du,2 Xiaona Li,3 Jing Yang,1 Xinyuan Zhang,1 Yuan Wei,1 Yangyu Zhao1 1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, National Center for Healthcare Quality Management in Obstetrics, Peking University Third Hospital, Beij...

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Autores principales:	Gong X, Du Y, Li X, Yang J, Zhang X, Wei Y, Zhao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	one-carbon metabolism betaine gestational diabetes mellitus twin pregnancy Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/250eea523c66424487ceadccbd9a602d
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spelling	oai:doaj.org-article:250eea523c66424487ceadccbd9a602d2021-12-02T14:54:25ZMaternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study1178-7007https://doaj.org/article/250eea523c66424487ceadccbd9a602d2021-06-01T00:00:00Zhttps://www.dovepress.com/maternal-plasma-betaine-in-middle-pregnancy-was-associated-with-decrea-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Xiaoli Gong,1 Yufeng Du,2 Xiaona Li,3 Jing Yang,1 Xinyuan Zhang,1 Yuan Wei,1 Yangyu Zhao1 1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, National Center for Healthcare Quality Management in Obstetrics, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 2Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, People’s Republic of China; 3Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, People’s Republic of ChinaCorrespondence: Yangyu Zhao; Yuan Wei Email zhaoyangyu001@163.com; weiyuanbysy@163.comPurpose: Although previous studies have shown that choline-related metabolites in one carbon metabolism (OCM) were related to gestational diabetes mellitus (GDM) risk in singleton pregnancy, their role in twin gestations remains unclear. We aimed to investigate the associations between choline, betaine, methionine, dimethylglycine (DMG), trimethylamine N-oxide (TMAO) and GDM risk among women with twin gestations.Patients and Methods: This hospital-based cohort study included 187 women with dichorionic twin gestations. Blood samples were collected during pregnancy at a median of 16.1 weeks of gestation (IQR: 13.9 − 17.9). Concentrations of plasma metabolites were measured by HPLC-triple quadrupole MS. Log-binomial regression models were applied to estimate the associations between plasma metabolites and the risk of GDM.Results: A total of 57 (30.5%) GDM cases were diagnosed over the study follow-up. Eighty-seven percent of women conceived through ART. Plasma betaine had an inverse association with GDM risk, and the adjusted RR of GDM comparing the highest tertile with the lowest tertile was 0.41 (95% CI: 0.19– 0.86, Ptrend=0.015). Women with a high betaine/choline ratio or a low DMG/betaine ratio were at decreased GDM risk (Ptrend=0.031 or 0.001, respectively). Plasma choline, methionine, DMG and TMAO were not associated with GDM risk.Conclusion: Among women with dichorionic twin gestations, higher plasma level of betaine in the second trimester was associated with lower risk of GDM. This finding needs further confirmation.Keywords: one-carbon metabolism, betaine, gestational diabetes mellitus, twin pregnancyGong XDu YLi XYang JZhang XWei YZhao YDove Medical Pressarticleone-carbon metabolismbetainegestational diabetes mellitustwin pregnancySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2495-2504 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	one-carbon metabolism betaine gestational diabetes mellitus twin pregnancy Specialties of internal medicine RC581-951
spellingShingle	one-carbon metabolism betaine gestational diabetes mellitus twin pregnancy Specialties of internal medicine RC581-951 Gong X Du Y Li X Yang J Zhang X Wei Y Zhao Y Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study
description	Xiaoli Gong,1 Yufeng Du,2 Xiaona Li,3 Jing Yang,1 Xinyuan Zhang,1 Yuan Wei,1 Yangyu Zhao1 1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, National Center for Healthcare Quality Management in Obstetrics, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 2Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, People’s Republic of China; 3Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, People’s Republic of ChinaCorrespondence: Yangyu Zhao; Yuan Wei Email zhaoyangyu001@163.com; weiyuanbysy@163.comPurpose: Although previous studies have shown that choline-related metabolites in one carbon metabolism (OCM) were related to gestational diabetes mellitus (GDM) risk in singleton pregnancy, their role in twin gestations remains unclear. We aimed to investigate the associations between choline, betaine, methionine, dimethylglycine (DMG), trimethylamine N-oxide (TMAO) and GDM risk among women with twin gestations.Patients and Methods: This hospital-based cohort study included 187 women with dichorionic twin gestations. Blood samples were collected during pregnancy at a median of 16.1 weeks of gestation (IQR: 13.9 − 17.9). Concentrations of plasma metabolites were measured by HPLC-triple quadrupole MS. Log-binomial regression models were applied to estimate the associations between plasma metabolites and the risk of GDM.Results: A total of 57 (30.5%) GDM cases were diagnosed over the study follow-up. Eighty-seven percent of women conceived through ART. Plasma betaine had an inverse association with GDM risk, and the adjusted RR of GDM comparing the highest tertile with the lowest tertile was 0.41 (95% CI: 0.19– 0.86, Ptrend=0.015). Women with a high betaine/choline ratio or a low DMG/betaine ratio were at decreased GDM risk (Ptrend=0.031 or 0.001, respectively). Plasma choline, methionine, DMG and TMAO were not associated with GDM risk.Conclusion: Among women with dichorionic twin gestations, higher plasma level of betaine in the second trimester was associated with lower risk of GDM. This finding needs further confirmation.Keywords: one-carbon metabolism, betaine, gestational diabetes mellitus, twin pregnancy
format	article
author	Gong X Du Y Li X Yang J Zhang X Wei Y Zhao Y
author_facet	Gong X Du Y Li X Yang J Zhang X Wei Y Zhao Y
author_sort	Gong X
title	Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study
title_short	Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study
title_full	Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study
title_fullStr	Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study
title_full_unstemmed	Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study
title_sort	maternal plasma betaine in middle pregnancy was associated with decreased risk of gdm in twin pregnancy: a cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/250eea523c66424487ceadccbd9a602d
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Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study

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