Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy

Abstract The purpose of this study is to evaluate the safety and efficacy of two novel heavy dyes for macular surgery: DoubledyneTM and TwinTM. One eye from each of 144 patients undergoing surgery for macular hole or macular pucker was included in the study. The eyes were randomly divided into two g...

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Autores principales:	Valerio Piccirillo, Sandro Sbordone, Francesco Sorgente, Adele Ragucci, Antonello Iovine, Gennarfrancesco Iaccarino, Michele Lanza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2510503378524ff0a6f020593c942b48
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spelling	oai:doaj.org-article:2510503378524ff0a6f020593c942b482021-12-02T16:31:48ZEvaluation of efficacy and safety of new high-density dyes for chromovitrectomy10.1038/s41598-021-94770-92045-2322https://doaj.org/article/2510503378524ff0a6f020593c942b482021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94770-9https://doaj.org/toc/2045-2322Abstract The purpose of this study is to evaluate the safety and efficacy of two novel heavy dyes for macular surgery: DoubledyneTM and TwinTM. One eye from each of 144 patients undergoing surgery for macular hole or macular pucker was included in the study. The eyes were randomly divided into two groups according to the dye used during surgery. Best correct visual acuity (BCVA), intraocular pressure (IOP) and retinal morphology assessed by ocular coherence tomography (OCT) were evaluated before and 1, 3, 6 and 12 months after surgery. Only one surgeon performed each operation and provided a score ranging from 1 (poor) to 10 (excellent) for quality of staining and comfort in surgery. Statistical analysis was carried out with SPSS to compare parameters before and after surgery and between the two groups. No statistical differences were recorded in quality of staining (p = 0.11), in surgery comfort (p = 0.17) and total time of surgery (p = 0.44) between the two groups. BCVA statistically improved and central macular thickness (CMT) statistically decreased after surgery in both groups (p < 0.05). No toxic dye-related complications or long-term ones affecting the retina were observed in either group. According to this data, although confirmation in further studies with larger populations and longer follow up is required, DoubledyneTM and TwinTM proved to be safe and effective dyes for macular surgery.Valerio PiccirilloSandro SbordoneFrancesco SorgenteAdele RagucciAntonello IovineGennarfrancesco IaccarinoMichele LanzaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valerio Piccirillo Sandro Sbordone Francesco Sorgente Adele Ragucci Antonello Iovine Gennarfrancesco Iaccarino Michele Lanza Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
description	Abstract The purpose of this study is to evaluate the safety and efficacy of two novel heavy dyes for macular surgery: DoubledyneTM and TwinTM. One eye from each of 144 patients undergoing surgery for macular hole or macular pucker was included in the study. The eyes were randomly divided into two groups according to the dye used during surgery. Best correct visual acuity (BCVA), intraocular pressure (IOP) and retinal morphology assessed by ocular coherence tomography (OCT) were evaluated before and 1, 3, 6 and 12 months after surgery. Only one surgeon performed each operation and provided a score ranging from 1 (poor) to 10 (excellent) for quality of staining and comfort in surgery. Statistical analysis was carried out with SPSS to compare parameters before and after surgery and between the two groups. No statistical differences were recorded in quality of staining (p = 0.11), in surgery comfort (p = 0.17) and total time of surgery (p = 0.44) between the two groups. BCVA statistically improved and central macular thickness (CMT) statistically decreased after surgery in both groups (p < 0.05). No toxic dye-related complications or long-term ones affecting the retina were observed in either group. According to this data, although confirmation in further studies with larger populations and longer follow up is required, DoubledyneTM and TwinTM proved to be safe and effective dyes for macular surgery.
format	article
author	Valerio Piccirillo Sandro Sbordone Francesco Sorgente Adele Ragucci Antonello Iovine Gennarfrancesco Iaccarino Michele Lanza
author_facet	Valerio Piccirillo Sandro Sbordone Francesco Sorgente Adele Ragucci Antonello Iovine Gennarfrancesco Iaccarino Michele Lanza
author_sort	Valerio Piccirillo
title	Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
title_short	Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
title_full	Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
title_fullStr	Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
title_full_unstemmed	Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
title_sort	evaluation of efficacy and safety of new high-density dyes for chromovitrectomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2510503378524ff0a6f020593c942b48
work_keys_str_mv	AT valeriopiccirillo evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy AT sandrosbordone evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy AT francescosorgente evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy AT adeleragucci evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy AT antonelloiovine evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy AT gennarfrancescoiaccarino evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy AT michelelanza evaluationofefficacyandsafetyofnewhighdensitydyesforchromovitrectomy
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Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy

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