Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections

Sindhu Priya Dhas, Suruthi Anbarasan, Amitava Mukherjee, Natarajan Chandrasekaran Center for Nanobiotechnology, VIT University, Vellore, India Abstract: Bombyx mori silk fibers are an important biomaterial and are used in surgical sutures due to their remarkable biocompatibility. The majo...

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Autores principales:	Dhas SP, Anbarasan S, Mukherjee A, Chandrasekaran N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/25161ea9267342e684ece0e60b70cb9b
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spelling	oai:doaj.org-article:25161ea9267342e684ece0e60b70cb9b2021-12-02T05:52:54ZBiobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections1178-2013https://doaj.org/article/25161ea9267342e684ece0e60b70cb9b2015-10-01T00:00:00Zhttps://www.dovepress.com/biobased-silver-nanocolloid-coating-on-silk-fibers-for-prevention-of-p-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sindhu Priya Dhas, Suruthi Anbarasan, Amitava Mukherjee, Natarajan Chandrasekaran Center for Nanobiotechnology, VIT University, Vellore, India Abstract: Bombyx mori silk fibers are an important biomaterial and are used in surgical sutures due to their remarkable biocompatibility. The major drawback to the application of biomaterials is the risk of bacterial invasion, leading to clinical complications. We have developed an easy and cost-effective method for fabrication of antibacterial silk fibers loaded with silver nanoparticles (AgNPs) by an in situ and ex situ process using an aqueous extract of Rhizophora apiculata leaf. Scanning electron microscopy revealed that well dispersed nanoparticles impregnated the silk fibers both in situ and ex situ. The crystalline nature of the AgNPs in the silk fibers was demonstrated by X-ray diffraction. The thermal and mechanical properties of the silk fibers were enhanced after they were impregnated with AgNPs. The silver-coated silk fibers fabricated by the in situ and ex situ method exhibited more than 90% inhibition against Pseudomonas aeruginosa and Staphylococcus aureus. Silk fibers doped with AgNPs were found to be biocompatible with 3T3 fibroblasts. The results obtained represent an important advance towards the clinical application of biocompatible AgNP-loaded silk fibers for prevention of surgical wound infections. Keywords: silk fibers, silver nanoparticles, antibacterial activity, wound infections, cytotoxicity, 3T3 fibroblast cellsDhas SPAnbarasan SMukherjee AChandrasekaran NDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Supplement 1 Challenges in biomaterials research, Pp 159-170 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dhas SP Anbarasan S Mukherjee A Chandrasekaran N Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
description	Sindhu Priya Dhas, Suruthi Anbarasan, Amitava Mukherjee, Natarajan Chandrasekaran Center for Nanobiotechnology, VIT University, Vellore, India Abstract: Bombyx mori silk fibers are an important biomaterial and are used in surgical sutures due to their remarkable biocompatibility. The major drawback to the application of biomaterials is the risk of bacterial invasion, leading to clinical complications. We have developed an easy and cost-effective method for fabrication of antibacterial silk fibers loaded with silver nanoparticles (AgNPs) by an in situ and ex situ process using an aqueous extract of Rhizophora apiculata leaf. Scanning electron microscopy revealed that well dispersed nanoparticles impregnated the silk fibers both in situ and ex situ. The crystalline nature of the AgNPs in the silk fibers was demonstrated by X-ray diffraction. The thermal and mechanical properties of the silk fibers were enhanced after they were impregnated with AgNPs. The silver-coated silk fibers fabricated by the in situ and ex situ method exhibited more than 90% inhibition against Pseudomonas aeruginosa and Staphylococcus aureus. Silk fibers doped with AgNPs were found to be biocompatible with 3T3 fibroblasts. The results obtained represent an important advance towards the clinical application of biocompatible AgNP-loaded silk fibers for prevention of surgical wound infections. Keywords: silk fibers, silver nanoparticles, antibacterial activity, wound infections, cytotoxicity, 3T3 fibroblast cells
format	article
author	Dhas SP Anbarasan S Mukherjee A Chandrasekaran N
author_facet	Dhas SP Anbarasan S Mukherjee A Chandrasekaran N
author_sort	Dhas SP
title	Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
title_short	Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
title_full	Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
title_fullStr	Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
title_full_unstemmed	Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
title_sort	biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/25161ea9267342e684ece0e60b70cb9b
work_keys_str_mv	AT dhassp biobasedsilvernanocolloidcoatingonsilkfibersforpreventionofpostsurgicalwoundinfections AT anbarasans biobasedsilvernanocolloidcoatingonsilkfibersforpreventionofpostsurgicalwoundinfections AT mukherjeea biobasedsilvernanocolloidcoatingonsilkfibersforpreventionofpostsurgicalwoundinfections AT chandrasekarann biobasedsilvernanocolloidcoatingonsilkfibersforpreventionofpostsurgicalwoundinfections
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Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections

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