Tracing the cellular basis of islet specification in mouse pancreas

The cellular basis of islet morphogenesis and fate allocation remain unclear. Here, the authors use a R26-CreER-R26R-Confetti mouse line to follow quantitatively the clonal dynamics of islet formation showing how, during the secondary transition, islet progenitors amplify through rounds of stochasti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Magdalena K. Sznurkowska, Edouard Hannezo, Roberta Azzarelli, Lemonia Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, Benjamin D. Simons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2516bc6a95c0469cbc1e4e1c8a53f059
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2516bc6a95c0469cbc1e4e1c8a53f059
record_format	dspace
spelling	oai:doaj.org-article:2516bc6a95c0469cbc1e4e1c8a53f0592021-12-02T19:16:24ZTracing the cellular basis of islet specification in mouse pancreas10.1038/s41467-020-18837-32041-1723https://doaj.org/article/2516bc6a95c0469cbc1e4e1c8a53f0592020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18837-3https://doaj.org/toc/2041-1723The cellular basis of islet morphogenesis and fate allocation remain unclear. Here, the authors use a R26-CreER-R26R-Confetti mouse line to follow quantitatively the clonal dynamics of islet formation showing how, during the secondary transition, islet progenitors amplify through rounds of stochastic cell division before becoming restricted to α and β cell sublineages.Magdalena K. SznurkowskaEdouard HannezoRoberta AzzarelliLemonia ChatzeliTatsuro IkedaShosei YoshidaAnna PhilpottBenjamin D. SimonsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magdalena K. Sznurkowska Edouard Hannezo Roberta Azzarelli Lemonia Chatzeli Tatsuro Ikeda Shosei Yoshida Anna Philpott Benjamin D. Simons Tracing the cellular basis of islet specification in mouse pancreas
description	The cellular basis of islet morphogenesis and fate allocation remain unclear. Here, the authors use a R26-CreER-R26R-Confetti mouse line to follow quantitatively the clonal dynamics of islet formation showing how, during the secondary transition, islet progenitors amplify through rounds of stochastic cell division before becoming restricted to α and β cell sublineages.
format	article
author	Magdalena K. Sznurkowska Edouard Hannezo Roberta Azzarelli Lemonia Chatzeli Tatsuro Ikeda Shosei Yoshida Anna Philpott Benjamin D. Simons
author_facet	Magdalena K. Sznurkowska Edouard Hannezo Roberta Azzarelli Lemonia Chatzeli Tatsuro Ikeda Shosei Yoshida Anna Philpott Benjamin D. Simons
author_sort	Magdalena K. Sznurkowska
title	Tracing the cellular basis of islet specification in mouse pancreas
title_short	Tracing the cellular basis of islet specification in mouse pancreas
title_full	Tracing the cellular basis of islet specification in mouse pancreas
title_fullStr	Tracing the cellular basis of islet specification in mouse pancreas
title_full_unstemmed	Tracing the cellular basis of islet specification in mouse pancreas
title_sort	tracing the cellular basis of islet specification in mouse pancreas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2516bc6a95c0469cbc1e4e1c8a53f059
work_keys_str_mv	AT magdalenaksznurkowska tracingthecellularbasisofisletspecificationinmousepancreas AT edouardhannezo tracingthecellularbasisofisletspecificationinmousepancreas AT robertaazzarelli tracingthecellularbasisofisletspecificationinmousepancreas AT lemoniachatzeli tracingthecellularbasisofisletspecificationinmousepancreas AT tatsuroikeda tracingthecellularbasisofisletspecificationinmousepancreas AT shoseiyoshida tracingthecellularbasisofisletspecificationinmousepancreas AT annaphilpott tracingthecellularbasisofisletspecificationinmousepancreas AT benjamindsimons tracingthecellularbasisofisletspecificationinmousepancreas
_version_	1718376902388875264

Tracing the cellular basis of islet specification in mouse pancreas

Ejemplares similares