A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.

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Autores principales: Thomas W Winkler, Felix Günther, Simon Höllerer, Martina Zimmermann, Ruth JF Loos, Zoltán Kutalik, Iris M Heid
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2516e462a68a41d99eb56cc05ac33e13
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spelling oai:doaj.org-article:2516e462a68a41d99eb56cc05ac33e132021-12-02T15:34:46ZA joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications10.1038/s41467-018-04124-92041-1723https://doaj.org/article/2516e462a68a41d99eb56cc05ac33e132018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04124-9https://doaj.org/toc/2041-1723In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.Thomas W WinklerFelix GüntherSimon HöllererMartina ZimmermannRuth JF LoosZoltán KutalikIris M HeidNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Thomas W Winkler
Felix Günther
Simon Höllerer
Martina Zimmermann
Ruth JF Loos
Zoltán Kutalik
Iris M Heid
A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
description In GWAS, waist-to-hip ratio (WHR) is often adjusted for body mass index (BMI) to account for their correlation (WHRadjBMI). Here, Winkler et al. classify 159 genetic variants for BMI, WHR, or WHRadjBMI based on their effect directions for BMI and WHR to differentiate subtypes of adiposity genetics.
format article
author Thomas W Winkler
Felix Günther
Simon Höllerer
Martina Zimmermann
Ruth JF Loos
Zoltán Kutalik
Iris M Heid
author_facet Thomas W Winkler
Felix Günther
Simon Höllerer
Martina Zimmermann
Ruth JF Loos
Zoltán Kutalik
Iris M Heid
author_sort Thomas W Winkler
title A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_short A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_full A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_fullStr A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_full_unstemmed A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
title_sort joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2516e462a68a41d99eb56cc05ac33e13
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