MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation
Batlle et al. identify the presence of coiled-coil (CC) domains that overlap with polyQ tracts in human proteins containing prion-like domains (PrLDs). They demonstrate that human MED15 Mediator complex subunit forms homodimers in solution mediated by coiled-coil interactions and that MED15CC aggreg...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/2517a586465644e7b440718bfabfa5ee |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!