Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting th...

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Autores principales:	John Tam, Therwa Hamza, Bing Ma, Kevin Chen, Greg L. Beilhartz, Jacques Ravel, Hanping Feng, Roman A. Melnyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25196c5f6826491d89346cd290d949ba
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spelling	oai:doaj.org-article:25196c5f6826491d89346cd290d949ba2021-12-02T17:31:31ZHost-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota10.1038/s41467-018-07705-w2041-1723https://doaj.org/article/25196c5f6826491d89346cd290d949ba2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07705-whttps://doaj.org/toc/2041-1723Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.John TamTherwa HamzaBing MaKevin ChenGreg L. BeilhartzJacques RavelHanping FengRoman A. MelnykNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John Tam Therwa Hamza Bing Ma Kevin Chen Greg L. Beilhartz Jacques Ravel Hanping Feng Roman A. Melnyk Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
description	Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.
format	article
author	John Tam Therwa Hamza Bing Ma Kevin Chen Greg L. Beilhartz Jacques Ravel Hanping Feng Roman A. Melnyk
author_facet	John Tam Therwa Hamza Bing Ma Kevin Chen Greg L. Beilhartz Jacques Ravel Hanping Feng Roman A. Melnyk
author_sort	John Tam
title	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_short	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_full	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_fullStr	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_full_unstemmed	Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
title_sort	host-targeted niclosamide inhibits c. difficile virulence and prevents disease in mice without disrupting the gut microbiota
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/25196c5f6826491d89346cd290d949ba
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Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

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