Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population

Abstract Blood urea nitrogen (BUN) is a nitrogenous end product of protein metabolism. This study aims to explore the age- and sex-specific distribution of BUN among healthy Chinese adults. A total of 24,006 BUN values from healthy adults (14,148 males and 9858 females) were included in the cross-se...

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Autores principales:	Qingquan Liu, Yiru Wang, Zhi Chen, Xiaolin Guo, Yongman Lv
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/251c2ddcfd004d9280e63de42678c1f3
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spelling	oai:doaj.org-article:251c2ddcfd004d9280e63de42678c1f32021-12-02T15:43:09ZAge- and sex-specific reference intervals for blood urea nitrogen in Chinese general population10.1038/s41598-021-89565-x2045-2322https://doaj.org/article/251c2ddcfd004d9280e63de42678c1f32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89565-xhttps://doaj.org/toc/2045-2322Abstract Blood urea nitrogen (BUN) is a nitrogenous end product of protein metabolism. This study aims to explore the age- and sex-specific distribution of BUN among healthy Chinese adults. A total of 24,006 BUN values from healthy adults (14,148 males and 9858 females) were included in the cross-sectional study. Males had a higher median BUN value compared to females (4.6 mmol/L vs. 4.1 mmol/L). BUN values showed a positive correlation with body mass index (BMI), cholesterol, and blood sugar (P < 0.0001). However, eGFR showed a negative correlation with the BUN reference value (P < 0.0001) in both sexes. Multiple linear regression analysis confirmed that the positive associations of BUN levels and age were statistically significant after adjusting confounding factors (P < 0.001). Thus, the serum BUN values increased by 0.21 mmol/L for males and 0.282 mmol/L for females per 10 years. The BUN values corresponding to the 1st, 2.5th, 50th, 97.5th, and 99th percentiles for any specific age in both sex were also calculated. These results indicate that the serum BUN reference value is significantly affected by age and gender, and thus, its interpretation is age- and sex-dependent.Qingquan LiuYiru WangZhi ChenXiaolin GuoYongman LvNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qingquan Liu Yiru Wang Zhi Chen Xiaolin Guo Yongman Lv Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population
description	Abstract Blood urea nitrogen (BUN) is a nitrogenous end product of protein metabolism. This study aims to explore the age- and sex-specific distribution of BUN among healthy Chinese adults. A total of 24,006 BUN values from healthy adults (14,148 males and 9858 females) were included in the cross-sectional study. Males had a higher median BUN value compared to females (4.6 mmol/L vs. 4.1 mmol/L). BUN values showed a positive correlation with body mass index (BMI), cholesterol, and blood sugar (P < 0.0001). However, eGFR showed a negative correlation with the BUN reference value (P < 0.0001) in both sexes. Multiple linear regression analysis confirmed that the positive associations of BUN levels and age were statistically significant after adjusting confounding factors (P < 0.001). Thus, the serum BUN values increased by 0.21 mmol/L for males and 0.282 mmol/L for females per 10 years. The BUN values corresponding to the 1st, 2.5th, 50th, 97.5th, and 99th percentiles for any specific age in both sex were also calculated. These results indicate that the serum BUN reference value is significantly affected by age and gender, and thus, its interpretation is age- and sex-dependent.
format	article
author	Qingquan Liu Yiru Wang Zhi Chen Xiaolin Guo Yongman Lv
author_facet	Qingquan Liu Yiru Wang Zhi Chen Xiaolin Guo Yongman Lv
author_sort	Qingquan Liu
title	Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population
title_short	Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population
title_full	Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population
title_fullStr	Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population
title_full_unstemmed	Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population
title_sort	age- and sex-specific reference intervals for blood urea nitrogen in chinese general population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/251c2ddcfd004d9280e63de42678c1f3
work_keys_str_mv	AT qingquanliu ageandsexspecificreferenceintervalsforbloodureanitrogeninchinesegeneralpopulation AT yiruwang ageandsexspecificreferenceintervalsforbloodureanitrogeninchinesegeneralpopulation AT zhichen ageandsexspecificreferenceintervalsforbloodureanitrogeninchinesegeneralpopulation AT xiaolinguo ageandsexspecificreferenceintervalsforbloodureanitrogeninchinesegeneralpopulation AT yongmanlv ageandsexspecificreferenceintervalsforbloodureanitrogeninchinesegeneralpopulation
_version_	1718385798945964032

Age- and sex-specific reference intervals for blood urea nitrogen in Chinese general population

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