D-serine mitigates cell loss associated with temporal lobe epilepsy

Temporal lobe epilepsy (TLE) can be unresponsive to treatment. Here, the authors show that treatment with D-Serine mitigates TLE and acts on neurons and glia, attenuating neuronal loss and reducing astro- and microgliosis in rodents.

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Autores principales: Stephen Beesley, Thomas Sullenberger, Kathryn Crotty, Roshan Ailani, Cameron D’Orio, Kimberly Evans, Emmanuel O. Ogunkunle, Michael G. Roper, Sanjay S. Kumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/251e82a043a74a02a6ee2fbc9ddc2d09
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Sumario:Temporal lobe epilepsy (TLE) can be unresponsive to treatment. Here, the authors show that treatment with D-Serine mitigates TLE and acts on neurons and glia, attenuating neuronal loss and reducing astro- and microgliosis in rodents.