D-serine mitigates cell loss associated with temporal lobe epilepsy

Temporal lobe epilepsy (TLE) can be unresponsive to treatment. Here, the authors show that treatment with D-Serine mitigates TLE and acts on neurons and glia, attenuating neuronal loss and reducing astro- and microgliosis in rodents.

Guardado en:

Detalles Bibliográficos
Autores principales:	Stephen Beesley, Thomas Sullenberger, Kathryn Crotty, Roshan Ailani, Cameron D’Orio, Kimberly Evans, Emmanuel O. Ogunkunle, Michael G. Roper, Sanjay S. Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/251e82a043a74a02a6ee2fbc9ddc2d09
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:251e82a043a74a02a6ee2fbc9ddc2d09
record_format	dspace
spelling	oai:doaj.org-article:251e82a043a74a02a6ee2fbc9ddc2d092021-12-02T18:51:37ZD-serine mitigates cell loss associated with temporal lobe epilepsy10.1038/s41467-020-18757-22041-1723https://doaj.org/article/251e82a043a74a02a6ee2fbc9ddc2d092020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18757-2https://doaj.org/toc/2041-1723Temporal lobe epilepsy (TLE) can be unresponsive to treatment. Here, the authors show that treatment with D-Serine mitigates TLE and acts on neurons and glia, attenuating neuronal loss and reducing astro- and microgliosis in rodents.Stephen BeesleyThomas SullenbergerKathryn CrottyRoshan AilaniCameron D’OrioKimberly EvansEmmanuel O. OgunkunleMichael G. RoperSanjay S. KumarNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen Beesley Thomas Sullenberger Kathryn Crotty Roshan Ailani Cameron D’Orio Kimberly Evans Emmanuel O. Ogunkunle Michael G. Roper Sanjay S. Kumar D-serine mitigates cell loss associated with temporal lobe epilepsy
description	Temporal lobe epilepsy (TLE) can be unresponsive to treatment. Here, the authors show that treatment with D-Serine mitigates TLE and acts on neurons and glia, attenuating neuronal loss and reducing astro- and microgliosis in rodents.
format	article
author	Stephen Beesley Thomas Sullenberger Kathryn Crotty Roshan Ailani Cameron D’Orio Kimberly Evans Emmanuel O. Ogunkunle Michael G. Roper Sanjay S. Kumar
author_facet	Stephen Beesley Thomas Sullenberger Kathryn Crotty Roshan Ailani Cameron D’Orio Kimberly Evans Emmanuel O. Ogunkunle Michael G. Roper Sanjay S. Kumar
author_sort	Stephen Beesley
title	D-serine mitigates cell loss associated with temporal lobe epilepsy
title_short	D-serine mitigates cell loss associated with temporal lobe epilepsy
title_full	D-serine mitigates cell loss associated with temporal lobe epilepsy
title_fullStr	D-serine mitigates cell loss associated with temporal lobe epilepsy
title_full_unstemmed	D-serine mitigates cell loss associated with temporal lobe epilepsy
title_sort	d-serine mitigates cell loss associated with temporal lobe epilepsy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/251e82a043a74a02a6ee2fbc9ddc2d09
work_keys_str_mv	AT stephenbeesley dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT thomassullenberger dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT kathryncrotty dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT roshanailani dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT camerondorio dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT kimberlyevans dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT emmanueloogunkunle dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT michaelgroper dserinemitigatescelllossassociatedwithtemporallobeepilepsy AT sanjayskumar dserinemitigatescelllossassociatedwithtemporallobeepilepsy
_version_	1718377374615076864

D-serine mitigates cell loss associated with temporal lobe epilepsy

Ejemplares similares