Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats

This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activiti...

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Autores principales:	Popović Nataša, Pajović B. Snežana, Stojiljković Vesna, Todorović Ana, Pejić Snežana, Pavlović Ivan, Gavrilović Ljubica
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	chronic restraint stress copper-zinc superoxide dismutase manganese superoxide dismutase catalase hippocampus rats Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/25232fe7505f4866a304f357582b1a01
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spelling	oai:doaj.org-article:25232fe7505f4866a304f357582b1a012021-11-17T21:27:51ZIncreased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats1820-744810.1515/acve-2017-0043https://doaj.org/article/25232fe7505f4866a304f357582b1a012017-12-01T00:00:00Zhttps://doi.org/10.1515/acve-2017-0043https://doaj.org/toc/1820-7448This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantifi ed by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our fi ndings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.Popović NatašaPajović B. SnežanaStojiljković VesnaTodorović AnaPejić SnežanaPavlović IvanGavrilović LjubicaSciendoarticlechronic restraint stresscopper-zinc superoxide dismutasemanganese superoxide dismutasecatalasehippocampusratsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 67, Iss 4, Pp 540-550 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic restraint stress copper-zinc superoxide dismutase manganese superoxide dismutase catalase hippocampus rats Veterinary medicine SF600-1100
spellingShingle	chronic restraint stress copper-zinc superoxide dismutase manganese superoxide dismutase catalase hippocampus rats Veterinary medicine SF600-1100 Popović Nataša Pajović B. Snežana Stojiljković Vesna Todorović Ana Pejić Snežana Pavlović Ivan Gavrilović Ljubica Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
description	This study examined the effects of chronic restraint stress (CRS: 2 hours × 14 days) on gene expression of three antioxidant enzymes, copper, zinc superoxide dismutase (SOD 1), manganese superoxide dismutase (SOD 2) and catalase (CAT) in the rat hippocampus. Also, we examined changes in the activities of SOD 1, SOD 2 and CAT in the hippocampus of chronically stressed rats. Investigated parameters were quantifi ed by using real-time RT-PCR, Western blot analysis and assay of enzymatic activity. We found that CRS did not change mRNA and protein levels of SOD 1 and CAT, but increased mRNA and protein levels of SOD 2. However, CRS treatment increased the enzyme activities of SOD 1, SOD 2 and CAT. Our fi ndings indicate that the increased activity of antioxidant enzymes (SOD 1, SOD 2 and CAT) in the hippocampus may be an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats.
format	article
author	Popović Nataša Pajović B. Snežana Stojiljković Vesna Todorović Ana Pejić Snežana Pavlović Ivan Gavrilović Ljubica
author_facet	Popović Nataša Pajović B. Snežana Stojiljković Vesna Todorović Ana Pejić Snežana Pavlović Ivan Gavrilović Ljubica
author_sort	Popović Nataša
title	Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
title_short	Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
title_full	Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
title_fullStr	Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
title_full_unstemmed	Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats
title_sort	increased activity of hippocampal antioxidant enzymes as an important adaptive phenomenon of the antioxidant defense system in chronically stressed rats
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/25232fe7505f4866a304f357582b1a01
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Increased Activity of Hippocampal Antioxidant Enzymes as an Important Adaptive Phenomenon of the Antioxidant Defense System in Chronically Stressed Rats

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