Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis

Objective: To compare the results of periodontal infrabony lesions treated using nanohydroxyapatite (NcHA) graft with other bone grafts (BGs). Methods: Four electronic databases were searched including PubMed (NLM), Embase (Ovid), Medline, and Dentistry and Oral Sciences (EBSCO). The inclusion crite...

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Autores principales: Muhammad Saad Shaikh, Muhammad Sohail Zafar, Ahmad Alnazzawi
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Lenguaje:EN
Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:2523e73fe8a04ac8b082d29ea91f59b32021-11-11T17:25:43ZComparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis10.3390/ijms2221120211422-00671661-6596https://doaj.org/article/2523e73fe8a04ac8b082d29ea91f59b32021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12021https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Objective: To compare the results of periodontal infrabony lesions treated using nanohydroxyapatite (NcHA) graft with other bone grafts (BGs). Methods: Four electronic databases were searched including PubMed (NLM), Embase (Ovid), Medline, and Dentistry and Oral Sciences (EBSCO). The inclusion criteria included randomised controlled clinical trials (RCTs) and controlled clinical trials (CCTs). The clinical results of NcHA were compared with other BGs. For clinical attachment level (CAL) gain, probing pocket depth (PPD) decrease, and gingival recession (REC) change, weighted averages and forest plots were computed. Results: Seven RCTs fulfilled the selection criteria that were included. When NcHA was compared to other BGs, no clinically significant differences were found in terms of each outcome assessed, except the REC change for synthetic BGs as compared to NcHA. Conclusions: The use of an NcHA graft showed equivalent results compared to other types of BGs. To further validate these findings, future studies are required to compare the NcHA and various BGs over longer time periods and in furcation deficiencies.Muhammad Saad ShaikhMuhammad Sohail ZafarAhmad AlnazzawiMDPI AGarticlenanohydroxyapatitebone graftsperiodontal regenerationinfrabony defectsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12021, p 12021 (2021)
institution DOAJ
collection DOAJ
language EN
topic nanohydroxyapatite
bone grafts
periodontal regeneration
infrabony defects
Biology (General)
QH301-705.5
Chemistry
QD1-999
spellingShingle nanohydroxyapatite
bone grafts
periodontal regeneration
infrabony defects
Biology (General)
QH301-705.5
Chemistry
QD1-999
Muhammad Saad Shaikh
Muhammad Sohail Zafar
Ahmad Alnazzawi
Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis
description Objective: To compare the results of periodontal infrabony lesions treated using nanohydroxyapatite (NcHA) graft with other bone grafts (BGs). Methods: Four electronic databases were searched including PubMed (NLM), Embase (Ovid), Medline, and Dentistry and Oral Sciences (EBSCO). The inclusion criteria included randomised controlled clinical trials (RCTs) and controlled clinical trials (CCTs). The clinical results of NcHA were compared with other BGs. For clinical attachment level (CAL) gain, probing pocket depth (PPD) decrease, and gingival recession (REC) change, weighted averages and forest plots were computed. Results: Seven RCTs fulfilled the selection criteria that were included. When NcHA was compared to other BGs, no clinically significant differences were found in terms of each outcome assessed, except the REC change for synthetic BGs as compared to NcHA. Conclusions: The use of an NcHA graft showed equivalent results compared to other types of BGs. To further validate these findings, future studies are required to compare the NcHA and various BGs over longer time periods and in furcation deficiencies.
format article
author Muhammad Saad Shaikh
Muhammad Sohail Zafar
Ahmad Alnazzawi
author_facet Muhammad Saad Shaikh
Muhammad Sohail Zafar
Ahmad Alnazzawi
author_sort Muhammad Saad Shaikh
title Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis
title_short Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis
title_full Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis
title_fullStr Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis
title_full_unstemmed Comparing Nanohydroxyapatite Graft and Other Bone Grafts in the Repair of Periodontal Infrabony Lesions: A Systematic Review and Meta-Analysis
title_sort comparing nanohydroxyapatite graft and other bone grafts in the repair of periodontal infrabony lesions: a systematic review and meta-analysis
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/2523e73fe8a04ac8b082d29ea91f59b3
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