Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology

This study tested the hypothesis that early life adversity (ELA) heightens psychopathology risk by concurrently altering pubertal and neurodevelopmental timing, and associated gene transcription signatures. Analyses focused on threat- (family conflict/neighbourhood crime) and deprivation-related ELA...

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Autores principales:	Raluca Petrican, Sian Miles, Lily Rudd, Wiktoria Wasiewska, Kim S. Graham, Andrew D. Lawrence
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neurodevelopment Early life adversity BOLD variability Structure-function coupling Functional brain networks Externalizing problems Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/25255b0632ee4c1f893a405f3cd72803
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spelling	oai:doaj.org-article:25255b0632ee4c1f893a405f3cd728032021-11-14T04:31:30ZPubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology1878-929310.1016/j.dcn.2021.101032https://doaj.org/article/25255b0632ee4c1f893a405f3cd728032021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878929321001213https://doaj.org/toc/1878-9293This study tested the hypothesis that early life adversity (ELA) heightens psychopathology risk by concurrently altering pubertal and neurodevelopmental timing, and associated gene transcription signatures. Analyses focused on threat- (family conflict/neighbourhood crime) and deprivation-related ELAs (parental inattentiveness/unmet material needs), using longitudinal data from 1514 biologically unrelated youths in the Adolescent Brain and Cognitive Development (ABCD) study. Typical developmental changes in white matter microstructure corresponded to widespread BOLD signal variability (BOLDsv) increases (linked to cell communication and biosynthesis genes) and region-specific task-related BOLDsv increases/decreases (linked to signal transduction, immune and external environmental response genes). Increasing resting-state (RS), but decreasing task-related BOLDsv predicted normative functional network segregation. Family conflict was the strongest concurrent and prospective contributor to psychopathology, while material deprivation constituted an additive risk factor. ELA-linked psychopathology was predicted by higher Time 1 threat-evoked BOLDSV (associated with axonal development, myelination, cell differentiation and signal transduction genes), reduced Time 2 RS BOLDsv (associated with cell metabolism and attention genes) and greater Time 1 to Time 2 control/attention network segregation. Earlier pubertal timing and neurodevelopmental alterations independently mediated ELA effects on psychopathology. Our results underscore the differential roles of the immediate and wider external environment(s) in concurrent and longer-term ELA consequences.Raluca PetricanSian MilesLily RuddWiktoria WasiewskaKim S. GrahamAndrew D. LawrenceElsevierarticleNeurodevelopmentEarly life adversityBOLD variabilityStructure-function couplingFunctional brain networksExternalizing problemsNeurophysiology and neuropsychologyQP351-495ENDevelopmental Cognitive Neuroscience, Vol 52, Iss , Pp 101032- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurodevelopment Early life adversity BOLD variability Structure-function coupling Functional brain networks Externalizing problems Neurophysiology and neuropsychology QP351-495
spellingShingle	Neurodevelopment Early life adversity BOLD variability Structure-function coupling Functional brain networks Externalizing problems Neurophysiology and neuropsychology QP351-495 Raluca Petrican Sian Miles Lily Rudd Wiktoria Wasiewska Kim S. Graham Andrew D. Lawrence Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
description	This study tested the hypothesis that early life adversity (ELA) heightens psychopathology risk by concurrently altering pubertal and neurodevelopmental timing, and associated gene transcription signatures. Analyses focused on threat- (family conflict/neighbourhood crime) and deprivation-related ELAs (parental inattentiveness/unmet material needs), using longitudinal data from 1514 biologically unrelated youths in the Adolescent Brain and Cognitive Development (ABCD) study. Typical developmental changes in white matter microstructure corresponded to widespread BOLD signal variability (BOLDsv) increases (linked to cell communication and biosynthesis genes) and region-specific task-related BOLDsv increases/decreases (linked to signal transduction, immune and external environmental response genes). Increasing resting-state (RS), but decreasing task-related BOLDsv predicted normative functional network segregation. Family conflict was the strongest concurrent and prospective contributor to psychopathology, while material deprivation constituted an additive risk factor. ELA-linked psychopathology was predicted by higher Time 1 threat-evoked BOLDSV (associated with axonal development, myelination, cell differentiation and signal transduction genes), reduced Time 2 RS BOLDsv (associated with cell metabolism and attention genes) and greater Time 1 to Time 2 control/attention network segregation. Earlier pubertal timing and neurodevelopmental alterations independently mediated ELA effects on psychopathology. Our results underscore the differential roles of the immediate and wider external environment(s) in concurrent and longer-term ELA consequences.
format	article
author	Raluca Petrican Sian Miles Lily Rudd Wiktoria Wasiewska Kim S. Graham Andrew D. Lawrence
author_facet	Raluca Petrican Sian Miles Lily Rudd Wiktoria Wasiewska Kim S. Graham Andrew D. Lawrence
author_sort	Raluca Petrican
title	Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
title_short	Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
title_full	Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
title_fullStr	Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
title_full_unstemmed	Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
title_sort	pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/25255b0632ee4c1f893a405f3cd72803
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Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology

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