RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.

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Auteurs principaux:	Pamela Valnegri, Ju Huang, Tomoko Yamada, Yue Yang, Luis A. Mejia, Ha Y. Cho, Anna Oldenborg, Azad Bonni
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2525626ed6774066921db5fb8eb36a6f
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spelling	oai:doaj.org-article:2525626ed6774066921db5fb8eb36a6f2021-12-02T14:40:47ZRNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain10.1038/s41467-017-01333-62041-1723https://doaj.org/article/2525626ed6774066921db5fb8eb36a6f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01333-6https://doaj.org/toc/2041-1723Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.Pamela ValnegriJu HuangTomoko YamadaYue YangLuis A. MejiaHa Y. ChoAnna OldenborgAzad BonniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pamela Valnegri Ju Huang Tomoko Yamada Yue Yang Luis A. Mejia Ha Y. Cho Anna Oldenborg Azad Bonni RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
description	Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.
format	article
author	Pamela Valnegri Ju Huang Tomoko Yamada Yue Yang Luis A. Mejia Ha Y. Cho Anna Oldenborg Azad Bonni
author_facet	Pamela Valnegri Ju Huang Tomoko Yamada Yue Yang Luis A. Mejia Ha Y. Cho Anna Oldenborg Azad Bonni
author_sort	Pamela Valnegri
title	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_short	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_full	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_fullStr	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_full_unstemmed	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_sort	rnf8/ubc13 ubiquitin signaling suppresses synapse formation in the mammalian brain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2525626ed6774066921db5fb8eb36a6f
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RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

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