RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.

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Autores principales: Pamela Valnegri, Ju Huang, Tomoko Yamada, Yue Yang, Luis A. Mejia, Ha Y. Cho, Anna Oldenborg, Azad Bonni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2525626ed6774066921db5fb8eb36a6f
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spelling oai:doaj.org-article:2525626ed6774066921db5fb8eb36a6f2021-12-02T14:40:47ZRNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain10.1038/s41467-017-01333-62041-1723https://doaj.org/article/2525626ed6774066921db5fb8eb36a6f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01333-6https://doaj.org/toc/2041-1723Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.Pamela ValnegriJu HuangTomoko YamadaYue YangLuis A. MejiaHa Y. ChoAnna OldenborgAzad BonniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pamela Valnegri
Ju Huang
Tomoko Yamada
Yue Yang
Luis A. Mejia
Ha Y. Cho
Anna Oldenborg
Azad Bonni
RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
description Ubiquitin ligases play critical roles in neuronal connectivity in the brain. Here, Valnegri and colleagues show that ubiquitin ligase RNF8 and ubiquitin-conjugating enzyme UBC13 regulate synapse number in cerebellar granule neurons and rodent cerebellar learning.
format article
author Pamela Valnegri
Ju Huang
Tomoko Yamada
Yue Yang
Luis A. Mejia
Ha Y. Cho
Anna Oldenborg
Azad Bonni
author_facet Pamela Valnegri
Ju Huang
Tomoko Yamada
Yue Yang
Luis A. Mejia
Ha Y. Cho
Anna Oldenborg
Azad Bonni
author_sort Pamela Valnegri
title RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_short RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_full RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_fullStr RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_full_unstemmed RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
title_sort rnf8/ubc13 ubiquitin signaling suppresses synapse formation in the mammalian brain
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2525626ed6774066921db5fb8eb36a6f
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