Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.

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Detalles Bibliográficos
Autores principales: Jennifer C. Chan, Christopher P. Morgan, N. Adrian Leu, Amol Shetty, Yasmine M. Cisse, Bridget M. Nugent, Kathleen E. Morrison, Eldin Jašarević, Weiliang Huang, Nickole Kanyuch, Ali B. Rodgers, Natarajan V. Bhanu, Dara S. Berger, Benjamin A. Garcia, Seth Ament, Maureen Kane, C. Neill Epperson, Tracy L. Bale
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/25257cea7d2d42d8a29025504d0f0690
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Sumario:Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.

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