Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.

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Autores principales:	Jennifer C. Chan, Christopher P. Morgan, N. Adrian Leu, Amol Shetty, Yasmine M. Cisse, Bridget M. Nugent, Kathleen E. Morrison, Eldin Jašarević, Weiliang Huang, Nickole Kanyuch, Ali B. Rodgers, Natarajan V. Bhanu, Dara S. Berger, Benjamin A. Garcia, Seth Ament, Maureen Kane, C. Neill Epperson, Tracy L. Bale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25257cea7d2d42d8a29025504d0f0690
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spelling	oai:doaj.org-article:25257cea7d2d42d8a29025504d0f06902021-12-02T15:39:13ZReproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment10.1038/s41467-020-15305-w2041-1723https://doaj.org/article/25257cea7d2d42d8a29025504d0f06902020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15305-whttps://doaj.org/toc/2041-1723Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.Jennifer C. ChanChristopher P. MorganN. Adrian LeuAmol ShettyYasmine M. CisseBridget M. NugentKathleen E. MorrisonEldin JašarevićWeiliang HuangNickole KanyuchAli B. RodgersNatarajan V. BhanuDara S. BergerBenjamin A. GarciaSeth AmentMaureen KaneC. Neill EppersonTracy L. BaleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer C. Chan Christopher P. Morgan N. Adrian Leu Amol Shetty Yasmine M. Cisse Bridget M. Nugent Kathleen E. Morrison Eldin Jašarević Weiliang Huang Nickole Kanyuch Ali B. Rodgers Natarajan V. Bhanu Dara S. Berger Benjamin A. Garcia Seth Ament Maureen Kane C. Neill Epperson Tracy L. Bale Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
description	Evidence for sperm small noncoding RNA-mediated intergenerational transmission implies communication from responsive somatic cells to sperm. Here, authors show that epididymal cells alter extracellular vesicle cargo after stress exposure, to impact offspring neurodevelopment and stress reactivity.
format	article
author	Jennifer C. Chan Christopher P. Morgan N. Adrian Leu Amol Shetty Yasmine M. Cisse Bridget M. Nugent Kathleen E. Morrison Eldin Jašarević Weiliang Huang Nickole Kanyuch Ali B. Rodgers Natarajan V. Bhanu Dara S. Berger Benjamin A. Garcia Seth Ament Maureen Kane C. Neill Epperson Tracy L. Bale
author_facet	Jennifer C. Chan Christopher P. Morgan N. Adrian Leu Amol Shetty Yasmine M. Cisse Bridget M. Nugent Kathleen E. Morrison Eldin Jašarević Weiliang Huang Nickole Kanyuch Ali B. Rodgers Natarajan V. Bhanu Dara S. Berger Benjamin A. Garcia Seth Ament Maureen Kane C. Neill Epperson Tracy L. Bale
author_sort	Jennifer C. Chan
title	Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
title_short	Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
title_full	Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
title_fullStr	Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
title_full_unstemmed	Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
title_sort	reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/25257cea7d2d42d8a29025504d0f0690
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Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment

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