Fasciculation differences between ALS and non-ALS patients: an ultrasound study

Abstract Background Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography (MUS) between ALS patients and non-ALS patients with symptoms resembling ALS. Methods Eight...

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Autores principales:	Jingwen Liu, Yi Li, Jingwen Niu, Lei Zhang, Jing Fan, Yuzhou Guan, Liying Cui, Mingsheng Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Amyotrophic lateral sclerosis Fasciculation Ultrasonography Peripheral neuropathy Diagnosis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2526f29eeabe4643b74361734bebdf36
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spelling	oai:doaj.org-article:2526f29eeabe4643b74361734bebdf362021-11-14T12:13:26ZFasciculation differences between ALS and non-ALS patients: an ultrasound study10.1186/s12883-021-02473-51471-2377https://doaj.org/article/2526f29eeabe4643b74361734bebdf362021-11-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02473-5https://doaj.org/toc/1471-2377Abstract Background Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography (MUS) between ALS patients and non-ALS patients with symptoms resembling ALS. Methods Eighty-eight ALS patients and fifty-four non-ALS (eight multifocal motor neuropathy, 32 chronic inflammatory demyelinating polyneuropathy/Charcot-Marie-Tooth, and 14 cervical spondylopathy or lumbar spondylopathy) patients were recruited. MUS was performed on 19 muscle groups in cervical, lumbosacral, bulbar, and thoracic regions for each patient. The intensity of fasciculation was divided into five grades based on firing frequency and number in the involved muscle groups. Results The overall detection rates were 72.8% in ALS and 18% in non-ALS patients. The fasciculation grades (median [IQR]) were 2 (0–3) in ALS and 0 (0–0) in non-ALS patients (P < 0.001). Fasciculations were observed in four regions for ALS patients and primarily distributed in proximal limbs. Fasciculations in non-ALS patients were primarily low-grade and mostly distributed in distal limbs. Discussion The fasciculation grade was higher in ALS than non-ALS patients. The distribution pattern of fasciculation was different between ALS and non-ALS patients. Conclusions The fasciculation grade and distribution pattern detected with MUS could help distinguish ALS from non-ALS patients.Jingwen LiuYi LiJingwen NiuLei ZhangJing FanYuzhou GuanLiying CuiMingsheng LiuBMCarticleAmyotrophic lateral sclerosisFasciculationUltrasonographyPeripheral neuropathyDiagnosisNeurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amyotrophic lateral sclerosis Fasciculation Ultrasonography Peripheral neuropathy Diagnosis Neurology. Diseases of the nervous system RC346-429
spellingShingle	Amyotrophic lateral sclerosis Fasciculation Ultrasonography Peripheral neuropathy Diagnosis Neurology. Diseases of the nervous system RC346-429 Jingwen Liu Yi Li Jingwen Niu Lei Zhang Jing Fan Yuzhou Guan Liying Cui Mingsheng Liu Fasciculation differences between ALS and non-ALS patients: an ultrasound study
description	Abstract Background Fasciculation is an important sign for the diagnosis of amyotrophic lateral sclerosis (ALS). Our study aimed to analyze the difference in fasciculation detected with muscle ultrasonography (MUS) between ALS patients and non-ALS patients with symptoms resembling ALS. Methods Eighty-eight ALS patients and fifty-four non-ALS (eight multifocal motor neuropathy, 32 chronic inflammatory demyelinating polyneuropathy/Charcot-Marie-Tooth, and 14 cervical spondylopathy or lumbar spondylopathy) patients were recruited. MUS was performed on 19 muscle groups in cervical, lumbosacral, bulbar, and thoracic regions for each patient. The intensity of fasciculation was divided into five grades based on firing frequency and number in the involved muscle groups. Results The overall detection rates were 72.8% in ALS and 18% in non-ALS patients. The fasciculation grades (median [IQR]) were 2 (0–3) in ALS and 0 (0–0) in non-ALS patients (P < 0.001). Fasciculations were observed in four regions for ALS patients and primarily distributed in proximal limbs. Fasciculations in non-ALS patients were primarily low-grade and mostly distributed in distal limbs. Discussion The fasciculation grade was higher in ALS than non-ALS patients. The distribution pattern of fasciculation was different between ALS and non-ALS patients. Conclusions The fasciculation grade and distribution pattern detected with MUS could help distinguish ALS from non-ALS patients.
format	article
author	Jingwen Liu Yi Li Jingwen Niu Lei Zhang Jing Fan Yuzhou Guan Liying Cui Mingsheng Liu
author_facet	Jingwen Liu Yi Li Jingwen Niu Lei Zhang Jing Fan Yuzhou Guan Liying Cui Mingsheng Liu
author_sort	Jingwen Liu
title	Fasciculation differences between ALS and non-ALS patients: an ultrasound study
title_short	Fasciculation differences between ALS and non-ALS patients: an ultrasound study
title_full	Fasciculation differences between ALS and non-ALS patients: an ultrasound study
title_fullStr	Fasciculation differences between ALS and non-ALS patients: an ultrasound study
title_full_unstemmed	Fasciculation differences between ALS and non-ALS patients: an ultrasound study
title_sort	fasciculation differences between als and non-als patients: an ultrasound study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2526f29eeabe4643b74361734bebdf36
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Fasciculation differences between ALS and non-ALS patients: an ultrasound study

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