CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION

The article presents results of multiplex cytokine assays in blood serum and lacrimal fluid at the initial and intermediate stages of age-related macular degeneration (AMD). Some features of local and systemic disturbances in the cytokine profile were detected in these patients. It was revealed that...

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Autores principales:	O. S. Slepova, E. A. Eremeeva, M. V. Ryabina, E. S. Sorozhkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	cytokines lacrimal fluid biomarkers macular degeneration Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2532d225b14347fcb024203d1992cd36
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spelling	oai:doaj.org-article:2532d225b14347fcb024203d1992cd362021-11-18T08:03:44ZCYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION1563-06252313-741X10.15789/1563-0625-2015-3-245-252https://doaj.org/article/2532d225b14347fcb024203d1992cd362015-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/889https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article presents results of multiplex cytokine assays in blood serum and lacrimal fluid at the initial and intermediate stages of age-related macular degeneration (AMD). Some features of local and systemic disturbances in the cytokine profile were detected in these patients. It was revealed that the initial stage of AMD was associated with elevated IL-17 levels in lacrimal fluid, along with imbalance between the local increase and systemic decrease of TGF-β1 amounts. Intermediate-stage AMD was associated with increased levels of the most cytokines assayed (except of TGF-β1) in blood serum and lacrimal fluid, thus suggesting stimulation of both pro-inflammatory and angiogenic responses, like as activation of anti-inflammatory and anti-infective factors.O. S. SlepovaE. A. EremeevaM. V. RyabinaE. S. SorozhkinaSPb RAACIarticlecytokineslacrimal fluidbiomarkersmacular degenerationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 3, Pp 245-252 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines lacrimal fluid biomarkers macular degeneration Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines lacrimal fluid biomarkers macular degeneration Immunologic diseases. Allergy RC581-607 O. S. Slepova E. A. Eremeeva M. V. Ryabina E. S. Sorozhkina CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
description	The article presents results of multiplex cytokine assays in blood serum and lacrimal fluid at the initial and intermediate stages of age-related macular degeneration (AMD). Some features of local and systemic disturbances in the cytokine profile were detected in these patients. It was revealed that the initial stage of AMD was associated with elevated IL-17 levels in lacrimal fluid, along with imbalance between the local increase and systemic decrease of TGF-β1 amounts. Intermediate-stage AMD was associated with increased levels of the most cytokines assayed (except of TGF-β1) in blood serum and lacrimal fluid, thus suggesting stimulation of both pro-inflammatory and angiogenic responses, like as activation of anti-inflammatory and anti-infective factors.
format	article
author	O. S. Slepova E. A. Eremeeva M. V. Ryabina E. S. Sorozhkina
author_facet	O. S. Slepova E. A. Eremeeva M. V. Ryabina E. S. Sorozhkina
author_sort	O. S. Slepova
title	CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
title_short	CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
title_full	CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
title_fullStr	CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
title_full_unstemmed	CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
title_sort	cytokines in lacrimal fluid and blood serum: early biomarkers of age-related macular degeneration
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/2532d225b14347fcb024203d1992cd36
work_keys_str_mv	AT osslepova cytokinesinlacrimalfluidandbloodserumearlybiomarkersofagerelatedmaculardegeneration AT eaeremeeva cytokinesinlacrimalfluidandbloodserumearlybiomarkersofagerelatedmaculardegeneration AT mvryabina cytokinesinlacrimalfluidandbloodserumearlybiomarkersofagerelatedmaculardegeneration AT essorozhkina cytokinesinlacrimalfluidandbloodserumearlybiomarkersofagerelatedmaculardegeneration
_version_	1718422403663527936

CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION

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