Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.

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Autores principales:	Urbain Weyemi, Bindu D. Paul, Adele M. Snowman, Parthav Jailwala, Andre Nussenzweig, William M. Bonner, Solomon H. Snyder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/253374c82ccd40c5a5caef64387f25f3
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spelling	oai:doaj.org-article:253374c82ccd40c5a5caef64387f25f32021-12-02T17:33:17ZHistone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis10.1038/s41467-018-03948-92041-1723https://doaj.org/article/253374c82ccd40c5a5caef64387f25f32018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03948-9https://doaj.org/toc/2041-1723H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.Urbain WeyemiBindu D. PaulAdele M. SnowmanParthav JailwalaAndre NussenzweigWilliam M. BonnerSolomon H. SnyderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Urbain Weyemi Bindu D. Paul Adele M. Snowman Parthav Jailwala Andre Nussenzweig William M. Bonner Solomon H. Snyder Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
description	H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.
format	article
author	Urbain Weyemi Bindu D. Paul Adele M. Snowman Parthav Jailwala Andre Nussenzweig William M. Bonner Solomon H. Snyder
author_facet	Urbain Weyemi Bindu D. Paul Adele M. Snowman Parthav Jailwala Andre Nussenzweig William M. Bonner Solomon H. Snyder
author_sort	Urbain Weyemi
title	Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
title_short	Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
title_full	Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
title_fullStr	Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
title_full_unstemmed	Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
title_sort	histone h2ax deficiency causes neurobehavioral deficits and impaired redox homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/253374c82ccd40c5a5caef64387f25f3
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Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis

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