Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells
Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss of RANK signaling in tumor cells drives a T ce...
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Nature Portfolio
2020
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oai:doaj.org-article:25343e5b801f4662be448798ebe81a762021-12-02T13:24:05ZInhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells10.1038/s41467-020-20138-82041-1723https://doaj.org/article/25343e5b801f4662be448798ebe81a762020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20138-8https://doaj.org/toc/2041-1723Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss of RANK signaling in tumor cells drives a T cell-dependent anti-tumor response in preclinical models.Clara Gómez-AlezaBastien NguyenGuillermo YoldiMarina CiscarAlexandra BarrancoEnrique Hernández-JiménezMarion MaetensRoberto SalgadoMaria ZafeiroglouPasquale PellegriniDavid VenetSoizic GaraudEva M. TrinidadSandra BenítezPeter VuylstekeLaura PolastroHans WildiersPhilippe SimonGeoffrey LindemanDenis LarsimontGert Van den EyndenChloé VelgheFrançoise RothéKaren Willard-GalloStefan MichielsPurificación MuñozThierry WalzerLourdes PlanellesJosef PenningerHatem A. AzimSherene LoiMartine PiccartChristos SotiriouEva González-SuárezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Clara Gómez-Aleza Bastien Nguyen Guillermo Yoldi Marina Ciscar Alexandra Barranco Enrique Hernández-Jiménez Marion Maetens Roberto Salgado Maria Zafeiroglou Pasquale Pellegrini David Venet Soizic Garaud Eva M. Trinidad Sandra Benítez Peter Vuylsteke Laura Polastro Hans Wildiers Philippe Simon Geoffrey Lindeman Denis Larsimont Gert Van den Eynden Chloé Velghe Françoise Rothé Karen Willard-Gallo Stefan Michiels Purificación Muñoz Thierry Walzer Lourdes Planelles Josef Penninger Hatem A. Azim Sherene Loi Martine Piccart Christos Sotiriou Eva González-Suárez Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells |
| description |
Receptor activator of nuclear factor-κB (RANK)/RANK-ligand (RANKL) signaling regulates the tumor-immune crosstalk. Here the authors show that systemic RANKL inhibition promotes CD8 + T cell infiltration in patients with early breast cancer and that loss of RANK signaling in tumor cells drives a T cell-dependent anti-tumor response in preclinical models. |
| format |
article |
| author |
Clara Gómez-Aleza Bastien Nguyen Guillermo Yoldi Marina Ciscar Alexandra Barranco Enrique Hernández-Jiménez Marion Maetens Roberto Salgado Maria Zafeiroglou Pasquale Pellegrini David Venet Soizic Garaud Eva M. Trinidad Sandra Benítez Peter Vuylsteke Laura Polastro Hans Wildiers Philippe Simon Geoffrey Lindeman Denis Larsimont Gert Van den Eynden Chloé Velghe Françoise Rothé Karen Willard-Gallo Stefan Michiels Purificación Muñoz Thierry Walzer Lourdes Planelles Josef Penninger Hatem A. Azim Sherene Loi Martine Piccart Christos Sotiriou Eva González-Suárez |
| author_facet |
Clara Gómez-Aleza Bastien Nguyen Guillermo Yoldi Marina Ciscar Alexandra Barranco Enrique Hernández-Jiménez Marion Maetens Roberto Salgado Maria Zafeiroglou Pasquale Pellegrini David Venet Soizic Garaud Eva M. Trinidad Sandra Benítez Peter Vuylsteke Laura Polastro Hans Wildiers Philippe Simon Geoffrey Lindeman Denis Larsimont Gert Van den Eynden Chloé Velghe Françoise Rothé Karen Willard-Gallo Stefan Michiels Purificación Muñoz Thierry Walzer Lourdes Planelles Josef Penninger Hatem A. Azim Sherene Loi Martine Piccart Christos Sotiriou Eva González-Suárez |
| author_sort |
Clara Gómez-Aleza |
| title |
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells |
| title_short |
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells |
| title_full |
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells |
| title_fullStr |
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells |
| title_full_unstemmed |
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells |
| title_sort |
inhibition of rank signaling in breast cancer induces an anti-tumor immune response orchestrated by cd8+ t cells |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/25343e5b801f4662be448798ebe81a76 |
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