Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy

Mona Khafaji,1 Masoud Zamani,2 Manouchehr Vossoughi,2,3 Azam Iraji zad1,4 1Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran 14588-89694, Iran; 2Institute for Biotechnology and Environment (IBE), Sharif University of Technology, Tehran, Iran; 3Department of Chemic...

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Autores principales:	Khafaji M, Zamani M, Vossoughi M, Iraji zad A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	iron oxide nanoparticles chemo/photothermal therapy dual-drug delivery control release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2536e7829a064f48ac8c394b14c37196
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spelling	oai:doaj.org-article:2536e7829a064f48ac8c394b14c371962021-12-02T04:41:00ZDoxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy1178-2013https://doaj.org/article/2536e7829a064f48ac8c394b14c371962019-11-01T00:00:00Zhttps://www.dovepress.com/doxorubicincisplatin-loaded-superparamagnetic-nanoparticles-as-a-stimu-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mona Khafaji,1 Masoud Zamani,2 Manouchehr Vossoughi,2,3 Azam Iraji zad1,4 1Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran 14588-89694, Iran; 2Institute for Biotechnology and Environment (IBE), Sharif University of Technology, Tehran, Iran; 3Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran; 4Department of Physics, Sharif University of Technology, Tehran 14588, IranCorrespondence: Mona KhafajiInstitute for Nanoscience and Nanotechnology, Sharif University of Technology, PO Box 11365-11155, Tehran 14588-89694, IranTel +98-21-66164123Fax +98-21-66164117Email mona.khafaji@gmail.comManouchehr VossoughiDepartment of Chemical and Petroleum Engineering, Sharif University of Technology, PO Box 11365-8639, Tehran, IranTel +98-21-66164104Fax +98-21-66005417Email vosoughi@sharif.eduIntroduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy.Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol (6 kDa) and carboxylate-methoxy polyethylene glycol (6 kDa) to improve their stability, biocompatibility, and drug loading capability. Doxorubicin (DOX) and cisplatin (CDDP) were loaded on the PS-IONs through the interactions between the drug molecules and polyethylene glycol.Results: The PS-IONs demonstrated excellent cellular uptake, cytocompatibility, and hemocompatibility at the practical dosage. Furthermore, in addition to being an appropriate MRI agent, PS-IONs demonstrated superb photothermal property in 0.5 W/cm2 of 808 nm laser irradiation. The release of both drugs was effectively triggered by pH and NIR irradiation. As a result of the intracellular combination chemotherapy and 10 min of safe power laser irradiation, the highest cytotoxicity for iron-based nanocarriers (97.3±0.8%) was achieved.Conclusion: The results of this study indicate the great potential of PS-IONs as a multifunctional targeted co-delivery system for cancer theranostic application and the advantage of employing proper combination therapy for cancer eradication.Keywords: iron oxide nanoparticles, chemo/photothermal therapy, dual-drug delivery, control releaseKhafaji MZamani MVossoughi MIraji zad ADove Medical Pressarticleiron oxide nanoparticleschemo/photothermal therapydual-drug deliverycontrol releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8769-8786 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron oxide nanoparticles chemo/photothermal therapy dual-drug delivery control release Medicine (General) R5-920
spellingShingle	iron oxide nanoparticles chemo/photothermal therapy dual-drug delivery control release Medicine (General) R5-920 Khafaji M Zamani M Vossoughi M Iraji zad A Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy
description	Mona Khafaji,1 Masoud Zamani,2 Manouchehr Vossoughi,2,3 Azam Iraji zad1,4 1Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran 14588-89694, Iran; 2Institute for Biotechnology and Environment (IBE), Sharif University of Technology, Tehran, Iran; 3Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran; 4Department of Physics, Sharif University of Technology, Tehran 14588, IranCorrespondence: Mona KhafajiInstitute for Nanoscience and Nanotechnology, Sharif University of Technology, PO Box 11365-11155, Tehran 14588-89694, IranTel +98-21-66164123Fax +98-21-66164117Email mona.khafaji@gmail.comManouchehr VossoughiDepartment of Chemical and Petroleum Engineering, Sharif University of Technology, PO Box 11365-8639, Tehran, IranTel +98-21-66164104Fax +98-21-66005417Email vosoughi@sharif.eduIntroduction: To date, numerous iron-based nanostructures have been designed for cancer therapy applications. Although some of them were promising for clinical applications, few efforts have been made to maximize the therapeutic index of these carriers. Herein, PEGylated silica-coated iron oxide nanoparticles (PS-IONs) were introduced as multipurpose stimuli-responsive co-delivery nanocarriers for a combination of dual-drug chemotherapy and photothermal therapy.Methods: Superparamagnetic iron oxide nanoparticles were synthesized via the sonochemical method and coated by a thin layer of silica. The nanostructures were then further modified with a layer of di-carboxylate polyethylene glycol (6 kDa) and carboxylate-methoxy polyethylene glycol (6 kDa) to improve their stability, biocompatibility, and drug loading capability. Doxorubicin (DOX) and cisplatin (CDDP) were loaded on the PS-IONs through the interactions between the drug molecules and polyethylene glycol.Results: The PS-IONs demonstrated excellent cellular uptake, cytocompatibility, and hemocompatibility at the practical dosage. Furthermore, in addition to being an appropriate MRI agent, PS-IONs demonstrated superb photothermal property in 0.5 W/cm2 of 808 nm laser irradiation. The release of both drugs was effectively triggered by pH and NIR irradiation. As a result of the intracellular combination chemotherapy and 10 min of safe power laser irradiation, the highest cytotoxicity for iron-based nanocarriers (97.3±0.8%) was achieved.Conclusion: The results of this study indicate the great potential of PS-IONs as a multifunctional targeted co-delivery system for cancer theranostic application and the advantage of employing proper combination therapy for cancer eradication.Keywords: iron oxide nanoparticles, chemo/photothermal therapy, dual-drug delivery, control release
format	article
author	Khafaji M Zamani M Vossoughi M Iraji zad A
author_facet	Khafaji M Zamani M Vossoughi M Iraji zad A
author_sort	Khafaji M
title	Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy
title_short	Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy
title_full	Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy
title_fullStr	Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy
title_full_unstemmed	Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy
title_sort	doxorubicin/cisplatin-loaded superparamagnetic nanoparticles as a stimuli-responsive co-delivery system for chemo-photothermal therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2536e7829a064f48ac8c394b14c37196
work_keys_str_mv	AT khafajim doxorubicincisplatinloadedsuperparamagneticnanoparticlesasastimuliresponsivecodeliverysystemforchemophotothermaltherapy AT zamanim doxorubicincisplatinloadedsuperparamagneticnanoparticlesasastimuliresponsivecodeliverysystemforchemophotothermaltherapy AT vossoughim doxorubicincisplatinloadedsuperparamagneticnanoparticlesasastimuliresponsivecodeliverysystemforchemophotothermaltherapy AT irajizada doxorubicincisplatinloadedsuperparamagneticnanoparticlesasastimuliresponsivecodeliverysystemforchemophotothermaltherapy
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Doxorubicin/Cisplatin-Loaded Superparamagnetic Nanoparticles As A Stimuli-Responsive Co-Delivery System For Chemo-Photothermal Therapy

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